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1.3.98.1: dihydroorotate dehydrogenase (fumarate)

This is an abbreviated version!
For detailed information about dihydroorotate dehydrogenase (fumarate), go to the full flat file.

Word Map on EC 1.3.98.1

Reaction

(S)-dihydroorotate
+
fumarate
=
Orotate
 +
succinate

Synonyms

(DHO) dehydrogenase, 4,5-L-dihydroorotate:oxygen oxidoreductase, ACT/DHOD, class 1A DHOD, class 1A DHODH, class 1A dihydroorotate dehydrogenase, DHOD, DHOD1, DHOD2, DHOD3, DHODA, DHOdehase, DHODH, DHODH-1A, dihydroorotate dehydrogenase, dihydroorotate dehydrogenase class 1A, Dihydroorotate oxidase, EC 1.3.3.1, LmDHODH, More, oxidase, dihydroorotate, TcDHOD

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.98 With other, known, physiological acceptors
                1.3.98.1 dihydroorotate dehydrogenase (fumarate)

Specific Activity

Specific Activity on EC 1.3.98.1 - dihydroorotate dehydrogenase (fumarate)

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0011
-
cytosolic fraction, native enzyme
0.06
-
using crotonate as electron acceptor
0.09
-
pH 8.0, 25°C, mutant N67A, substrate O2
0.11
-
pH 8.0, 25°C, mutant N67A, substrate dichlorophenolindophenol
0.14
-
pH 8.0, 25°C, mutant N193A, substrate fumarate
0.17
-
pH 8.0, 25°C, mutant N193A, substrate O2
0.3
-
pH 8.0, 25°C, mutant N67A, substrate fumarate
0.47
-
pH 8.0, 25°C, mutant P56A, substrate dichlorophenolindophenol
0.48
-
pH 8.0, 25°C, mutant P56A, substrate fumarate
0.75
-
pH 8.0, 25°C, mutant N127A, substrate dichlorophenolindophenol
0.94
-
using mesaconate as electron acceptor
0.987
-
using 0.02 mM ubiquinone-1 as acceptor, at 25°C
1
-
pH 8.0, 25°C, mutant N127A, substrate O2
1.2
-
pH 8.0, 25°C, mutant N127A, substrate fumarate
1.4
-
at 37°C, 5 mM sodium diphosphate buffer
1.6
-
pH 8.0, 25°C, mutant K136E, substrate O2
1.61
-
purified native enzyme, electron acceptor fumarate
1.8
-
pH 8.0, 25°C, mutant S129A, substrate O2
1.81
-
using O2 as electron acceptor
1.9
-
pH 8.0, 25°C, mutant K213E, substrate O2
11.7
-
pH 8.0, 25°C, mutant S129A, substrate dichlorophenolindophenol
117.5
-
with ferricyanide as acceptor
13
-
pH 8.0, 25°C, mutant K136E, substrate dichlorophenolindophenol
13.6
-
pH 8.0, 25°C, wild-type, substrate dichlorophenolindophenol
15.8
-
pH 8.0, 25°C, wild-type, substrate fumarate
151000
-
cosubstrate fumarate, pH 7.5
18.1
-
pH 8.0, 25°C, mutant K136E, substrate fumarate
19
-
pH 8.0, 25°C, mutant R50E, substrate fumarate
2
-
pH 8.0, 25°C, wild-type, substrate O2
2.3
-
pH 8.0, 25°C, mutant P131A, substrate O2
2.4
-
pH 8.0, 25°C, mutant K213E, substrate dichlorophenolindophenol
2.8
-
pH 8.0, 25°C, mutant S129A, substrate fumarate
2.95
-
purified recombinant enzyme, electron acceptor fumarate
27
-
pH 8.0, 25°C, mutant R57A, substrate fumarate
3.318
-
using 0.5 mM fumarate as acceptor, at 25°C
3.7
-
pH 8.0, 25°C, mutant P131A, substrate fumarate
3.99
-
pH 9.0, 37°C
3948
-
pH 8.5, 70°C
4
-
pH 8.0, 25°C, mutant P131A, substrate dichlorophenolindophenol
5.1
-
using fumarate as electron acceptor
65.7
-
pH 8.0, 25°C, mutant R57A, substrate dichlorophenolindophenol