1.3.98.1: dihydroorotate dehydrogenase (fumarate)
This is an abbreviated version!
For detailed information about dihydroorotate dehydrogenase (fumarate), go to the full flat file.
Word Map on EC 1.3.98.1
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1.3.98.1
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pyrimidine
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leflunomide
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brequinar
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uridine
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plasmodium
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falciparum
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ubiquinone
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teriflunomide
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dhods
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1.3.3.1
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ump
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dihydro-orotate
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triazolopyrimidine
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atovaquone
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1.3.99.11
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dysostosis
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analysis
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medicine
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acrofacial
- 1.3.98.1
- pyrimidine
- leflunomide
- brequinar
- uridine
- plasmodium
- falciparum
- ubiquinone
- teriflunomide
-
dhods
-
1.3.3.1
- ump
-
dihydro-orotate
- triazolopyrimidine
- atovaquone
-
1.3.99.11
- dysostosis
- analysis
- medicine
-
acrofacial
Reaction
Synonyms
(DHO) dehydrogenase, 4,5-L-dihydroorotate:oxygen oxidoreductase, ACT/DHOD, class 1A DHOD, class 1A DHODH, class 1A dihydroorotate dehydrogenase, DHOD, DHOD1, DHOD2, DHOD3, DHODA, DHOdehase, DHODH, DHODH-1A, dihydroorotate dehydrogenase, dihydroorotate dehydrogenase class 1A, Dihydroorotate oxidase, EC 1.3.3.1, LmDHODH, More, oxidase, dihydroorotate, TcDHOD
ECTree
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KM Value
KM Value on EC 1.3.98.1 - dihydroorotate dehydrogenase (fumarate)
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0.0131
2,3-dimethoxy-5-methyl-6-(3-methyl-2-butenyl)-1,4-benzoquinone
at saturating concentration of dihydroorotate
0.115
2,6-dichloroindophenol
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in 50mM Tris/HCl, 150 mM KCl, 0.1% (v/v) Triton X-100, pH 8, at 30°C
additional information
additional information
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10% v/v dimethyl sulfoxide and 0.5% v/vTriton X-100, which seem to facilitate the substrate binding process with a small decrease in Km, enzyme-substrate complex, pseudo-first-order kinetics, thermodynamics, overview
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0.00856
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assay based on isothermal titration calorimetry, pH 8.0, 25°C
0.12
fumarate
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pH not specified in the publication, temperature not specified in the publication
0.12
fumarate
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assay based on isothermal titration calorimetry, pH 8.0, 25°C
0.0086
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pH not specified in the publication, temperature not specified in the publication
0.016
L-dihydroorotate
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in 50mM Tris/HCl, 150 mM KCl, 0.1% (v/v) Triton X-100, pH 8, at 30°C
0.5
S-dihydroorotate
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with ferricyanide as electron acceptor