1.3.8.7: medium-chain acyl-CoA dehydrogenase

This is an abbreviated version, for detailed information about medium-chain acyl-CoA dehydrogenase, go to the full flat file.

Reaction

a medium-chain acyl-CoA
+
electron-transfer flavoprotein
=
a medium-chain trans-2,3-dehydroacyl-CoA
+
reduced electron-transfer flavoprotein

Synonyms

ACAD-9, ACADM, ACD, acyl CoA dehydrogenase, acyl coenzyme A dehydrogenase, acyl dehydrogenase, acyl-CoA dehydrogenase, acyl-CoA dehydrogenase-9, dehydrogenase, acyl coenzyme A, EC 1.3.2.2, FadE, fatty acyl coenzyme A dehydrogenase, fatty-acyl-CoA dehydrogenase, general ACAD, general acyl CoA dehydrogenase, LCAD, LipB, MCAD, MCADH, medium chain acyl-CoA dehydrogenase, medium chain-specific acyl-CoA oxidase, medium-chain acyl CoA dehydrogenase, medium-chain acyl-CoA dehydrogenase, medium-chain acyl-coenzyme A dehydrogenase, medium-chain coenzyme A dehydrogenase, pMCAD, PP_1893, PP_2039, PP_2048, PP_2437

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.8 With a flavin as acceptor
                1.3.8.7 medium-chain acyl-CoA dehydrogenase

Turnover Number

Turnover Number on EC 1.3.8.7 - medium-chain acyl-CoA dehydrogenase

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
6.2 - 11.5
Butanoyl-CoA
0.00233 - 0.00783
crotonyl-CoA
-
hydratase activity, value depending on pH
0.233 - 11.7
decanoyl-CoA
7
dodecadecanoyl-coA
-
-
3.33 - 9.5
Dodecanoyl-CoA
11.6
electron transfer flavoprotein
-
-
1.17 - 2.33
electron transferring flavoprotein
12
electron transferring protein
-
between pH 8.0 and pH 10.0 at a ionic strength between 11 mM and 50 mM, lower values at acidic pH and with higher ionic strength
-
18.3
ferricenium hexafluorophosphate
-
medium chain acyl-CoA dehydrogenase from kidney
13.2 - 13.6
furylpropionyl-CoA
0.617 - 2.92
hexadecanoyl-CoA
2.83 - 31.2
Hexanoyl-CoA
0.016 - 3.4
indolepropionyl-CoA
0.1
meldola's blue
-
medium chain acyl-CoA dehydrogenase from kidney, terminal acceptor iodonitrotetrazolium
0.667
Octadecanoyl-CoA
-
K304E mutant enzyme, ferricenium assay
0.0024 - 35.7
Octanoyl-CoA
0.235
octanoyl-pantetheine
-
general acyl-CoA dehydrogenase
0.75
phenazine ethosulfate
-
medium chain acyl-CoA dehydrogenase from kidney, terminal acceptor 2,6-dichlorphenol-indophenol
3
phenazine methosulfate
-
medium chain acyl-CoA dehydrogenase from kidney, terminal acceptor 2,6-dichlorphenol-indophenol
1.67 - 18.3
recombinant beta-Y16L electron transferring flavoprotein
-
1 - 14.7
recombinant electron transferring flavoprotein
-
2.67 - 8.33
tetradecanoyl-CoA
0.61 - 4.6
[4-(dimethylamino)phenyl]propionyl-CoA