1.3.8.7: medium-chain acyl-CoA dehydrogenase

This is an abbreviated version, for detailed information about medium-chain acyl-CoA dehydrogenase, go to the full flat file.

Reaction

a medium-chain acyl-CoA
+
electron-transfer flavoprotein
=
a medium-chain trans-2,3-dehydroacyl-CoA
+
reduced electron-transfer flavoprotein

Synonyms

ACAD-9, ACADM, ACD, acyl CoA dehydrogenase, acyl coenzyme A dehydrogenase, acyl dehydrogenase, acyl-CoA dehydrogenase, acyl-CoA dehydrogenase-9, dehydrogenase, acyl coenzyme A, EC 1.3.2.2, FadE, fatty acyl coenzyme A dehydrogenase, fatty-acyl-CoA dehydrogenase, general ACAD, general acyl CoA dehydrogenase, LCAD, LipB, MCAD, MCADH, medium chain acyl-CoA dehydrogenase, medium chain-specific acyl-CoA oxidase, medium-chain acyl CoA dehydrogenase, medium-chain acyl-CoA dehydrogenase, medium-chain acyl-coenzyme A dehydrogenase, medium-chain coenzyme A dehydrogenase, pMCAD, PP_1893, PP_2039, PP_2048, PP_2437

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.8 With a flavin as acceptor
                1.3.8.7 medium-chain acyl-CoA dehydrogenase

Substrates Products

Substrates Products on EC 1.3.8.7 - medium-chain acyl-CoA dehydrogenase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(4Z,7Z,10Z,13Z,16Z,19Z)-4,7,10,13,16,19-docosahexaenoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
show the reaction diagram
-
-
-
-
-
(5Z,8Z,11Z,14Z,17Z) -5,8,11,14,17-icosapentaenoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
show the reaction diagram
-
-
-
-
-
2,6-dimethylheptanoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
show the reaction diagram
-
-
-
-
-
4,8,12-trimethyltridecanoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
show the reaction diagram
-
-
-
-
-
4-cis,7-cis-decadienoyl-CoA + Meldola's Blue + iodonitrotetrazoliumchloride
2-trans,4-cis,7cis-decatrienoyl-CoA + reduced acceptor
show the reaction diagram
-
cis-double bond has almost no effect on velocity of general acyl-CoA dehydrogenase
-
?
4-cis-decenoyl-CoA + Meldola's Blue + iodonitrotetrazoliumchloride
2-trans,4-cis-decadienoyl-CoA + reduced acceptor
show the reaction diagram
-
cis-double bond has almost no effect on velocity of general acyl-CoA dehydrogenase
-
?
4-decynoyl-CoA + Meldola's Blue + iodonitrotetrazoliumchloride
trans-2-ene-4-decynoyl-CoA + reduced acceptor
show the reaction diagram
-
cis-double bond has almost no effect on velocity of general acyl-CoA dehydrogenase
-
?
4-oxaoctanoyl-CoA + phenazine methosulfate + 2,6-dichlorophenolindophenol
4-thia-trans-2-octenoyl-CoA + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
-
poor substrate, oxidized at about 10% of the rate of octanoyl-CoA
-
?
4-thiaoctanoyl-CoA + phenazine methosulfate + 2,6-dichlorophenolindophenol
4-thia-trans-2-octenoyl-CoA + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
-
oxidized 1.5fold faster than octanoyl-CoA
-
?
5-cis-decenoyl-CoA + Meldola's Blue + iodonitrotetrazoliumchloride
2-trans,5-cis-decadienoyl-CoA + reduced acceptor
show the reaction diagram
-
cis-double bond has almost no effect on velocity of general acyl-CoA dehydrogenase
-
?
6-cis-decenoyl-CoA + Meldola's Blue + iodonitrotetrazoliumchloride
2-trans,6-cis-decadienoyl-CoA + reduced acceptor
show the reaction diagram
-
cis-double bond has almost no effect on velocity of general acyl-CoA dehydrogenase
-
?
acyl-CoA + acceptor
2,3-dehydroacyl-CoA + reduced acceptor
show the reaction diagram
acyl-CoA + electron transfer flavoprotein
2,3-dehydroacyl-CoA + reduced electron transfer flavoprotein
show the reaction diagram
all-cis-4,7,10,13-hexadecatetraenoyl-CoA + Meldola's Blue + iodonitrotetrazoliumchloride
2-trans-all-cis-4,7,10,13-hexadecapentaenoyl-CoA + reduced acceptor
show the reaction diagram
-
cis-double bond has almost no effect on velocity of general acyl-CoA dehydrogenase
-
?
arachidonoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
show the reaction diagram
-
-
-
-
-
arachidoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
show the reaction diagram
-
-
-
-
-
beta-(2-furyl)propionyl-CoA + electron transfer flavoprotein + 2,6-dichloroindophenol
trans-beta-(2-furyl)acryloyl-CoA + reduced acceptor
show the reaction diagram
beta-(2-furyl)propionyl-CoA + O2
trans-beta-(2-furyl)acryloyl-CoA + H2O2
show the reaction diagram
-
slow oxidase activity
-
?
beta-(2-furyl)propionyl-CoA + pyocyanine
trans-beta-(2-furyl)acryloyl-CoA + reduced pyocanine
show the reaction diagram
-
-
-
?
butanoyl-CoA + acceptor
crotonyl-CoA + reduced acceptor
show the reaction diagram
crotonyl-CoA + H2O
L-3-hydroxy-butyryl-CoA
show the reaction diagram
-
enoyl-CoA hydratase activity
-
?
decanoyl-CoA + acceptor
2-decenoyl-CoA + reduced acceptor
show the reaction diagram
decanoyl-CoA + electron transfer flavoprotein
decenoyl-CoA + reduced electron transfer flavoprotein
show the reaction diagram
decanoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
show the reaction diagram
-
-
-
-
-
decanoyl-CoA + phenazine methosulfate + 2,6-dichloroindophenol
2-trans-decenoyl-CoA + reduced acceptor
show the reaction diagram
docosanoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
show the reaction diagram
-
-
-
-
-
dodecanoyl-CoA + acceptor
2-dodecenoyl-CoA + reduced acceptor
show the reaction diagram
dodecanoyl-CoA + electron transfer flavoprotein
dodecenoyl-CoA + reduced electron transfer flavoprotein
show the reaction diagram
elaidoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
show the reaction diagram
-
-
-
-
-
furylpropionyl-CoA + ferricenium hexafluorophosphate
furylacryloyl-CoA + ferrocenium hexafluorophosphate
show the reaction diagram
heptadecan-2-onyl-dethio-CoA + phenazine methosulfate + 2,6-dichloroindophenol
?
show the reaction diagram
heptadecanoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
show the reaction diagram
-
-
-
-
-
hexadecanoyl-CoA + acceptor
2-hexadecenoyl-CoA + reduced acceptor
show the reaction diagram
hexadecanoyl-CoA + Meldola's Blue + iodonitrotetrazoliumchloride
2-trans-hexadecenoyl-CoA + reduced acceptor
show the reaction diagram
hexanoyl-CoA + 2,6-dichloroindophenol
2-hexenoyl-CoA + reduced 2,6-dichloroindophenol
show the reaction diagram
-
-
-
-
?
hexanoyl-CoA + acceptor
2-hexenoyl-CoA + reduced acceptor
show the reaction diagram
hexanoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
show the reaction diagram
-
-
-
-
-
hexanoyl-CoA + phenazine methosulfate + 2,6-dichloroindophenol
2-trans-hexenoyl-CoA + reduced acceptor
show the reaction diagram
-
-
-
?
indolepropionyl-CoA + ferricenium hexafluorophosphate
indoleacryloyl-CoA + ferrocenium hexafluorophosphate
show the reaction diagram
indolepropionyl-CoA + O2
indoleacryloyl-CoA + H2O2
show the reaction diagram
lauroyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
show the reaction diagram
-
-
-
-
-
lauryl-CoA + phenazine methosulfate + 2,6-dichloroindophenol
2-trans-dodecenoyl-CoA + reduced acceptor
show the reaction diagram
-
-
-
?
linoleoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
show the reaction diagram
-
-
-
-
-
myristoleoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
show the reaction diagram
-
-
-
-
-
myristoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
show the reaction diagram
-
-
-
-
-
n-octanoyl-CoA + acceptor
2-octenoyl-CoA + reduced acceptor
show the reaction diagram
-
-
-
-
?
n-octanoyl-CoA + phenazine methosulfate + 2,6-dichloroindophenol
2-octenoyl-CoA + reduced acceptor
show the reaction diagram
n-tetradecanoyl-CoA + phenazine methosulfate + 2,6-dichloroindophenol
2-tetradecenoyl-CoA + reduced acceptor
show the reaction diagram
nonanoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
show the reaction diagram
-
-
-
-
-
octadecanoyl-CoA + acceptor
2-octadecenoyl-CoA + reduced acceptor
show the reaction diagram
octanoyl 3'-dephospho-CoA + 2,6-dichloroindophenol
?
show the reaction diagram
-
-
-
-
?
octanoyl pantetheine + 2,6-dichloroindophenol
?
show the reaction diagram
-
-
-
-
?
octanoyl-1,N6-etheno-CoA + 2,6-dichloroindophenol
?
show the reaction diagram
-
-
-
-
?
octanoyl-CoA + 2,6-dichloroindophenol
2-octenoyl-CoA + reduced 2,6-dichloroindophenol
show the reaction diagram
-
optimal substrate for wild type enzyme
-
-
?
octanoyl-CoA + acceptor
2-octenoyl-CoA + reduced acceptor
show the reaction diagram
octanoyl-CoA + electron transferring flavoprotein
2-octenoyl-CoA + reduced electron transferring flavoprotein
show the reaction diagram
octanoyl-CoA + ferricenium
2-octenoyl-CoA + reduced acceptor
show the reaction diagram
octanoyl-CoA + ferricenium hexafluorophosphate
2-octenoyl-CoA + ferrocenium hexafluorophosphate
show the reaction diagram
-
medium chain acyl-CoA dehydrogenase from kidney
-
?
octanoyl-CoA + ferriocenium hexfluorophosphate
2-octenoyl-CoA + reduced acceptor
show the reaction diagram
-
-
-
-
?
octanoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
show the reaction diagram
-
-
-
-
-
octanoyl-CoA + phenazine methosulfate + 2,6-dichloroindophenol
2-octenoyl-CoA + reduced acceptor
show the reaction diagram
-
-
-
-
?
oleoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
show the reaction diagram
-
-
-
-
-
palmitoleoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
show the reaction diagram
-
-
-
-
-
palmitoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
show the reaction diagram
-
-
-
-
-
pentadecanoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
show the reaction diagram
-
-
-
-
-
pentanoyl-CoA + acceptor
2-pentenoyl-CoA + reduced acceptor
show the reaction diagram
phenylpropionyl-CoA + acceptor
? + reduced acceptor
show the reaction diagram
phenylpropionyl-CoA + ferricenium hexafluorophosphate
? + reduced ferricenium hexafluorophosphate
show the reaction diagram
-
-
-
-
?
stearoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
show the reaction diagram
-
-
-
-
-
tetradecanoyl-CoA + acceptor
2-tetradecenoyl-CoA + reduced acceptor
show the reaction diagram
tetradecanoyl-CoA + electron transfer flavoprotein
tetradecenoyl-CoA + reduced electron transfer flavoprotein
show the reaction diagram
undecanoyl-CoA + oxidized electron transfer flavoprotein
? + reduced electron transfer flavoprotein
show the reaction diagram
-
-
-
-
-
[4-(dimethylamino)phenyl]propionyl-CoA + ferricenium hexafluorophosphate
4-(dimethylamino)cinnamoyl-CoA + ferrocenium hexafluorophosphate
show the reaction diagram
additional information
?
-