1.3.8.7: medium-chain acyl-CoA dehydrogenase

This is an abbreviated version, for detailed information about medium-chain acyl-CoA dehydrogenase, go to the full flat file.

Reaction

a medium-chain acyl-CoA
+
electron-transfer flavoprotein
=
a medium-chain trans-2,3-dehydroacyl-CoA
+
reduced electron-transfer flavoprotein

Synonyms

ACAD-9, ACADM, ACD, acyl CoA dehydrogenase, acyl coenzyme A dehydrogenase, acyl dehydrogenase, acyl-CoA dehydrogenase, acyl-CoA dehydrogenase-9, dehydrogenase, acyl coenzyme A, EC 1.3.2.2, FadE, fatty acyl coenzyme A dehydrogenase, fatty-acyl-CoA dehydrogenase, general ACAD, general acyl CoA dehydrogenase, LCAD, LipB, MCAD, MCADH, medium chain acyl-CoA dehydrogenase, medium chain-specific acyl-CoA oxidase, medium-chain acyl CoA dehydrogenase, medium-chain acyl-CoA dehydrogenase, medium-chain acyl-coenzyme A dehydrogenase, medium-chain coenzyme A dehydrogenase, pMCAD, PP_1893, PP_2039, PP_2048, PP_2437

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.8 With a flavin as acceptor
                1.3.8.7 medium-chain acyl-CoA dehydrogenase

Specific Activity

Specific Activity on EC 1.3.8.7 - medium-chain acyl-CoA dehydrogenase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.004
-
activity in extracts of strain CB13 grown on oleic acid as carbon source
0.043
-
; activity in extracts of strain CB15 grown on oleic acid as carbon source
0.076
-
substrate butanoyl-CoA
0.08
-
activity in cells grown on triolein, barely detectable activity in glucose-grown cells
0.168
-
substrate hexadecanoyl-CoA
0.272
-
substrate octanoyl-CoA
1.96
-
long-chain acyl-CoA dehydrogenase
4.46
-
substrate indolepropionyl-CoA, ferrocenium hexafluorophosphate as electron carrier
6.75
-
-
10 - 10.2
-
-
10.6
-
assessed by measuring the amount of product formed in the first 5 min by gas chromatographic analysis
10.7
-
dye reduction assay with 2,6-dichlorophenolindophenol
11.9
-
medium-chain acyl-CoA dehydrogenase
17.5
-
recombinant K304E mutant enzyme, measured with ferricenium assay
24.9
-
recombinant wild-type enzyme, measured with ferricenium assay