1.3.8.7: medium-chain acyl-CoA dehydrogenase

This is an abbreviated version, for detailed information about medium-chain acyl-CoA dehydrogenase, go to the full flat file.

Reaction

a medium-chain acyl-CoA
+
electron-transfer flavoprotein
=
a medium-chain trans-2,3-dehydroacyl-CoA
+
reduced electron-transfer flavoprotein

Synonyms

ACAD-9, ACD, acyl CoA dehydrogenase, acyl coenzyme A dehydrogenase, acyl dehydrogenase, acyl-CoA dehydrogenase, acyl-CoA dehydrogenase-9, dehydrogenase, acyl coenzyme A, EC 1.3.2.2, fatty acyl coenzyme A dehydrogenase, fatty-acyl-CoA dehydrogenase, general ACAD, general acyl CoA dehydrogenase, LCAD, LipB, MCAD, MCADH, medium chain acyl-CoA dehydrogenase, medium chain-specific acyl-CoA oxidase, medium-chain acyl CoA dehydrogenase, medium-chain acyl-CoA dehydrogenase, medium-chain acyl-coenzyme A dehydrogenase, medium-chain coenzyme A dehydrogenase, pMCAD

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.8 With a flavin as acceptor
                1.3.8.7 medium-chain acyl-CoA dehydrogenase

Inhibitors

Inhibitors on EC 1.3.8.7 - medium-chain acyl-CoA dehydrogenase

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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(Methylenecyclopropyl)acetyl-CoA
(R)-(-)-(methylenecyclopropyl)acetyl-CoA
(S)-(+)-(Methylenecyclopropyl)acetyl-CoA
-
stereospecific inactivation, faster inhibition with (R)-isomer than with (S)-isomer
1-ethyl-3(3-dimethylaminopropyl)-carbodiimide
-
90-96% inhibition of activity with electron transfer flavoprotein, not with phenazine methosulfate
2,3-octadienoyl-CoA
-
-
2-decenoyl-CoA
-
medium- and long-chain acyl-CoA dehydrogenase
2-hexadecenoyl-CoA
-
competitive, long-chain acyl-CoA dehdrogenase
2-octenoyl-CoA
-
-
2-octynoyl-CoA
3,4-pentadienoyl-CoA
-
suicide substrate, 0.1 mM almost complete inhibition
3-butynoyl-CoA
-
concentration-dependent, progressive total inactivation, active site inhibitor
3-ketodecanoyl-CoA
-
medium- and long-chain acyl-CoA dehydrogenase
3-ketooctanoyl-CoA
-
76% inhibition
3-oxaoctanoyl-CoA
-
-
3-thiaoctanoyl-CoA
-
-
4-oxaoctanoyl-CoA
-
-
4-thiaoctanoyl-CoA
-
-
acetoacetyl-CoA
-
-
crotonyl-CoA
-
-
diethyldicarbonate
-
rapid inactivation
DL-3-hydroxydecenoyl-CoA
-
-
HgCl2
iodoacetamide
-
2 mM, 73% inhibition
iodoacetic acid
L-3-hydroxyoctanoyl-CoA
-
0.03 mM, 7% inhibition
Methylmercury chloride
-
0.1 mM, strong inhibition
Methylmercury iodide
N-ethylmaleimide
oct-2-yn-4-enoyl-CoA
-
pH-dependent inactivation
oct-4-en-2-ynoyl-CoA
-
irreversible inhibitor, active-site directed, enzyme protected by 2-octenoyl-CoA
Octanoyl-CoA
-
0.0045 mM, 98% inhibition of enoyl-CoA hydratase activity
octenoyl-CoA
-
competitive, medium-chain acyl-CoA dehydrogenase
Octyl-CoA
-
-
p-chloromercuribenzoate
p-hydroxymercuribenzoate
-
0.1 mM, almost complete inhibition of the apo-enzyme
S-Heptadecyl-CoA
-
competitive inhibition
semiquinone electron transfer flavoprotein
-
-
-
trans-2-octenoyl-CoA
-
0.03 mM, 62% inhibition
trans-3-octenoyl-CoA
-
0.03 mM, 67% inhibition
additional information
-