1.3.8.5: short-chain 2-methylacyl-CoA dehydrogenase

This is an abbreviated version!
For detailed information about short-chain 2-methylacyl-CoA dehydrogenase, go to the full flat file.

Reaction

Synonyms

2-methyl branched chain acyl-CoA dehydrogenase, 2-Methyl branched-chain acyl-CoA dehydrogenase, 2-Methyl branched-chain enoyl CoA reductase, 2-Methyl branched-chain enoyl-CoA reductase, 2-methylbutyryl-CoA dehydrogenase, 2MBCD, branched chain acyl-CoA dehydrogenase, EC 1.3.99.12, ECR, Methyl branched-chain enoyl-CoA reductase, Reductase, methyl branched-chain enoyl coenzyme A, SBCAD, SBCADD, short/branched chain acyl-CoA dehydrogenase

ECTree

     1 Oxidoreductases

         1.3 Acting on the CH-CH group of donors

             1.3.8 With a flavin as acceptor

                1.3.8.5 short-chain 2-methylacyl-CoA dehydrogenase

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Results	in table
132	AA Sequence
1	CAS Registry Number
6	Cloned(Commentary)
5	Cofactor
68	Disease/ Diagnostics
28	Inhibitors
2	Ki Value [mM]
30	KM Value [mM]
5	Localization
10	Molecular Weight [Da]
11	Natural Substrates/ Products (Substrates)
13	Organism
11	Pathway
3	pH Optimum
11	Protein Variants
7	Purification (Commentary)
4	Reaction
2	Reaction Type
13	Reference
14	Source Tissue
10	Specific Activity [micromol/min/mg]
1	Storage Stability
42	Substrates and Products (Substrate)
8	Subunits
19	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
22	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 1.3.8.5 - short-chain 2-methylacyl-CoA dehydrogenase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

(R)-2-methylbutanoyl-CoA + electron-transfer flavoprotein

2-methylbut-2-enoyl-CoA + reduced electron-transfer flavoprotein + H+

2 entries

(R)-2-methylbutyryl-CoA + acceptor

2-ethylprop-2-enoyl-CoA + reduced acceptor

2 entries

(S)-2-methylbutanoyl-CoA + acceptor

2-methylbut-2-enoyl-CoA + reduced acceptor

3 entries

(S)-2-methylbutanoyl-CoA + electron-transfer flavoprotein

2-methylbut-2-enoyl-CoA + reduced electron-transfer flavoprotein + H+

4 entries

2-methylbutanoyl-CoA + electron transfer flavoprotein

2-methylbut-2-enoyl-CoA + reduced electron transfer flavoprotein

4 entries

2-methylbutanoyl-CoA + electron-transfer flavoprotein

(E)-2-methylbut-2-enoyl-CoA + reduced electron-transfer flavoprotein + H+

Ascaris suum

O16843

-

12302

-

12302

?

2-methylpentanoyl-CoA + electron-transfer flavoprotein

2-methyl-2-pentenoyl-CoA + reduced electron-transfer flavoprotein + H+

Ascaris suum

O16843

98% of the activity with 2-methylbutanoyl-CoA

12302

-

12302

?

butyryl-CoA + acceptor

2-butenoyl-CoA + reduced acceptor

Rattus norvegicus

-

5% of activity with 2-methylbutyryl-CoA

391254

-

-

?

butyryl-CoA + electron-transfer flavoprotein

? + reduced electron-transfer flavoprotein + H+

Ascaris suum

O16843

13.6% of the activity with 2-methylbutanoyl-CoA

12302

-

-

?

butyryl-CoA + electron-transfer flavoprotein

but-2-enoyl-CoA + reduced electron-transfer flavoprotein + H+

Solanum tuberosum

-

-

656288

-

-

?

hexanoyl-CoA + electron-transfer flavoprotein

hex-2-enoyl-CoA + reduced electron-transfer flavoprotein

3 entries

isobutyryl-CoA + acceptor

methacrylyl-CoA + reduced acceptor

3 entries

isobutyryl-CoA + electron-transfer flavoprotein

2-methylacryloyl-CoA + reduced electron-transfer flavoprotein + H+

2 entries

isovaleryl-CoA + phenazine methosulfate

?

Rattus norvegicus

-

-

391203

-

-

r

octanoyl-CoA + electron-transfer flavoprotein

? + reduced electron-transfer flavoprotein + H+

Ascaris suum

O16843

12.8% of the activity with 2-methylbutanoyl-CoA

12302

-

-

?

octanoyl-CoA + electron-transfer flavoprotein

oct-2-enoyl-CoA + reduced electron-transfer flavoprotein + H+

Solanum tuberosum

-

-

656288

-

-

?

pentanoyl-CoA + electron-transfer flavoprotein

? + reduced electron-transfer flavoprotein + H+

Ascaris suum

O16843

14.4% of the activity with 2-methylbutanoyl-CoA

12302

-

-

?

valeryl-CoA + electron-transfer flavoprotein

pent-2-enoyl-CoA + reduced electron-transfer flavoprotein + H+

Solanum tuberosum

-

-

656288

-

-

?

additional information

?

-

11 entries

(R)-2-methylbutanoyl-CoA + electron-transfer flavoprotein

2-methylbut-2-enoyl-CoA + reduced electron-transfer flavoprotein + H+

Homo sapiens

-

-

655243

i.e. ethylacrylyl-CoA

-

?

(R)-2-methylbutanoyl-CoA + electron-transfer flavoprotein

2-methylbut-2-enoyl-CoA + reduced electron-transfer flavoprotein + H+

Homo sapiens

-

involved in the (S)-pathway of L-isoleucine oxidation, and also in the (R)-pathway of L-alloisoleucine oxidation due to interconvertion of the 3 isomers

655243

-

-

?

(R)-2-methylbutyryl-CoA + acceptor

2-ethylprop-2-enoyl-CoA + reduced acceptor

Rattus norvegicus

-

-

391254

-

391254

?

(R)-2-methylbutyryl-CoA + acceptor

2-ethylprop-2-enoyl-CoA + reduced acceptor

Rattus norvegicus

-

22% of activity with (S)-2-methylbutyryl-CoA

391252

-

391252

?

(S)-2-methylbutanoyl-CoA + acceptor

2-methylbut-2-enoyl-CoA + reduced acceptor

Rattus norvegicus

-

acceptors: electron transfer flavoprotein, phenazine methosulfate, meldola's blue

391203

-

391203

r

(S)-2-methylbutanoyl-CoA + acceptor

2-methylbut-2-enoyl-CoA + reduced acceptor

Rattus norvegicus

-

acceptors: electron transfer flavoprotein, phenazine methosulfate, meldola's blue

391252

-

391252

r

(S)-2-methylbutanoyl-CoA + acceptor

2-methylbut-2-enoyl-CoA + reduced acceptor

Rattus norvegicus

-

acceptors: electron transfer flavoprotein, phenazine methosulfate, meldola's blue

391254

-

391254

r

(S)-2-methylbutanoyl-CoA + electron-transfer flavoprotein

2-methylbut-2-enoyl-CoA + reduced electron-transfer flavoprotein + H+

Homo sapiens

-

-

656162

-

-

?

(S)-2-methylbutanoyl-CoA + electron-transfer flavoprotein

2-methylbut-2-enoyl-CoA + reduced electron-transfer flavoprotein + H+

Homo sapiens

-

-

655243

i.e. tiglyl-CoA

-

?

(S)-2-methylbutanoyl-CoA + electron-transfer flavoprotein

2-methylbut-2-enoyl-CoA + reduced electron-transfer flavoprotein + H+

Homo sapiens

-

involved in the (S)-pathway of L-isoleucine oxidation, and also in the (R)-pathway of L-alloisoleucine oxidation due to interconvertion of the 3 isomers

655243

-

-

?

(S)-2-methylbutanoyl-CoA + electron-transfer flavoprotein

2-methylbut-2-enoyl-CoA + reduced electron-transfer flavoprotein + H+

Rattus norvegicus

-

-

656162

-

-

?

2-methylbutanoyl-CoA + electron transfer flavoprotein

2-methylbut-2-enoyl-CoA + reduced electron transfer flavoprotein

Rattus norvegicus

-

-

391203

-

391203

r

2-methylbutanoyl-CoA + electron transfer flavoprotein

2-methylbut-2-enoyl-CoA + reduced electron transfer flavoprotein

Rattus norvegicus

-

-

391254

-

391254

r

2-methylbutanoyl-CoA + electron transfer flavoprotein

2-methylbut-2-enoyl-CoA + reduced electron transfer flavoprotein

Rattus norvegicus

-

enzyme catalyzes the third step in the oxidative metabolism of isoleucin and valine

391252

-

391252

r

2-methylbutanoyl-CoA + electron transfer flavoprotein

2-methylbut-2-enoyl-CoA + reduced electron transfer flavoprotein

Solanum tuberosum

-

-

656288

-

-

?

hexanoyl-CoA + electron-transfer flavoprotein

hex-2-enoyl-CoA + reduced electron-transfer flavoprotein

Homo sapiens

-

41% of activity with (S)-2-methylbutanoyl-CoA

656162

-

-

?

hexanoyl-CoA + electron-transfer flavoprotein

hex-2-enoyl-CoA + reduced electron-transfer flavoprotein

Rattus norvegicus

-

8% of activity with (S)-2-methylbutanoyl-CoA, wild-type enzyme

656162

-

-

?

hexanoyl-CoA + electron-transfer flavoprotein

hex-2-enoyl-CoA + reduced electron-transfer flavoprotein

Solanum tuberosum

-

-

656288

-

-

?

isobutyryl-CoA + acceptor

methacrylyl-CoA + reduced acceptor

Rattus norvegicus

-

-

391203

-

391203

?

isobutyryl-CoA + acceptor

methacrylyl-CoA + reduced acceptor

Rattus norvegicus

-

-

391252

-

391252

?

isobutyryl-CoA + acceptor

methacrylyl-CoA + reduced acceptor

Rattus norvegicus

-

-

391254

-

391254

?

isobutyryl-CoA + electron-transfer flavoprotein

2-methylacryloyl-CoA + reduced electron-transfer flavoprotein + H+

Homo sapiens

-

6% of activity with (S)-2-methylbutanoyl-CoA

656162

-

-

?

isobutyryl-CoA + electron-transfer flavoprotein

2-methylacryloyl-CoA + reduced electron-transfer flavoprotein + H+

Rattus norvegicus

-

37% of activity with (S)-2-methylbutanoyl-CoA, wild-type enzyme

656162

-

-

?

additional information

?

-

Ascaris suum

O16843

no reaction with: propionyl-CoA, isobutanoyl-CoA, isopentanoyl-CoA, palmitoyl-CoA

12302

-

-

?

additional information

?

-

Ascaris suum

-

no reaction with: propionyl-CoA, isobutanoyl-CoA, isopentanoyl-CoA, palmitoyl-CoA

12302

-

-

?

additional information

?

-

Ascaris suum

-

the enzyme plays a pivotal role in the reversal of beta-oxidation operating in anaerobic mitochondria of the parasitic nematode Ascaris suum

12304

-

-

?

additional information

?

-

Ascaris suum

-

the enzyme plays a pivotal role in the reversal of beta-oxidation operating in anaerobic mitochondria of the parasitic nematode Ascaris suum

12305

-

-

?

additional information

?

-

Ascaris suum

-

the enzyme plays a pivotal role in the reversal of beta-oxidation operating in anaerobic mitochondria of the parasitic nematode Ascaris suum

12306

-

-

?

additional information

?

-

Ascaris suum

O16843

the electron-transport chain of the organism and the enzyme 2-methyl-branched-chain-enoyl-CoA reductase are responsible for the NADH-dependent reduction of the branched-chain enoyl-CoAs observed in mitochondria

12302

-

-

?

additional information

?

-

Ascaris suum

-

the electron-transport chain of the organism and the enzyme 2-methyl-branched-chain-enoyl-CoA reductase are responsible for the NADH-dependent reduction of the branched-chain enoyl-CoAs observed in mitochondria

12302

-

-

?

additional information

?

-

Ascaris suum

-

expression of the enzyme is tissue-specific and developmentally regulated

12305

-

-

?

additional information

?

-

Homo sapiens

-

enzyme deficiency causes 2-ethylhydracrylic aciduria with excretion f 2-methylbutyrylglycine

655243

-

-

?

additional information

?

-

Rattus norvegicus

-

substrate specificity of wild-type and mutants, overview

656162

-

-

?

additional information

?

-

Solanum tuberosum

-

no activity with isovaleryl-CoA

656288

-

-

?