1.3.8.5: short-chain 2-methylacyl-CoA dehydrogenase

This is an abbreviated version!
For detailed information about short-chain 2-methylacyl-CoA dehydrogenase, go to the full flat file.

Reaction

Synonyms

2-methyl branched chain acyl-CoA dehydrogenase, 2-Methyl branched-chain acyl-CoA dehydrogenase, 2-Methyl branched-chain enoyl CoA reductase, 2-Methyl branched-chain enoyl-CoA reductase, 2-methylbutyryl-CoA dehydrogenase, 2MBCD, branched chain acyl-CoA dehydrogenase, EC 1.3.99.12, ECR, Methyl branched-chain enoyl-CoA reductase, Reductase, methyl branched-chain enoyl coenzyme A, SBCAD, SBCADD, short/branched chain acyl-CoA dehydrogenase

ECTree

     1 Oxidoreductases

         1.3 Acting on the CH-CH group of donors

             1.3.8 With a flavin as acceptor

                1.3.8.5 short-chain 2-methylacyl-CoA dehydrogenase

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Results	in table
132	AA Sequence
1	CAS Registry Number
6	Cloned(Commentary)
5	Cofactor
68	Disease/ Diagnostics
28	Inhibitors
2	Ki Value [mM]
30	KM Value [mM]
5	Localization
10	Molecular Weight [Da]
11	Natural Substrates/ Products (Substrates)
13	Organism
11	Pathway
3	pH Optimum
11	Protein Variants
7	Purification (Commentary)
4	Reaction
2	Reaction Type
13	Reference
14	Source Tissue
10	Specific Activity [micromol/min/mg]
1	Storage Stability
42	Substrates and Products (Substrate)
8	Subunits
19	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
22	Turnover Number [1/s]

Engineering

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Engineering on EC 1.3.8.5 - short-chain 2-methylacyl-CoA dehydrogenase

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PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

A383T

Rattus norvegicus

-

site-directed mutagenesis, altered substrate specificity compared to the wild-type enzyme

656162

E107D/L112V/T115K/I117K

Rattus norvegicus

-

site-directed mutagenesis, mutant is not stable

656162

F105L

Rattus norvegicus

-

site-directed mutagenesis, altered substrate specificity compared to the wild-type enzyme

656162

L220M/A383T

Rattus norvegicus

-

site-directed mutagenesis, altered substrate specificity compared to the wild-type enzyme

656162

L220M/L222I

Rattus norvegicus

-

site-directed mutagenesis, altered substrate specificity compared to the wild-type enzyme

656162

L220M/L222I/A383T

Rattus norvegicus

-

site-directed mutagenesis, altered substrate specificity compared to the wild-type enzyme

656162

L222I/A383T

Rattus norvegicus

-

site-directed mutagenesis, altered substrate specificity compared to the wild-type enzyme

656162

S177N

Rattus norvegicus

-

site-directed mutagenesis, altered substrate specificity compared to the wild-type enzyme

656162

V104L

Rattus norvegicus

-

site-directed mutagenesis, altered substrate specificity compared to the wild-type enzyme

656162

V104L/F105L

Rattus norvegicus

-

site-directed mutagenesis, altered substrate specificity compared to the wild-type enzyme

656162

additional information

Rattus norvegicus

-

construction of deletion mutants, substrate specificity and catalytic efficiency, overview

656162