1.3.8.4: isovaleryl-CoA dehydrogenase

This is an abbreviated version!
For detailed information about isovaleryl-CoA dehydrogenase, go to the full flat file.

Word Map on EC 1.3.8.4

Reaction

isovaleryl-CoA
+
electron-transfer flavoprotein
=
3-methylcrotonyl-CoA
+
reduced electron-transfer flavoprotein

Synonyms

acyl-CoA dehydrogenase, i3VD, iso(3)valeryl-CoA dehydrogenase, isovaleric-CoA dehydrogenase, isovaleroyl-coenzyme A dehydrogenase, isovaleryl-coenzyme A dehydrogenase, IVD, IVDH, LiuA, SBCAD, short/branched chain acyl-CoA dehydrogenase

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.8 With a flavin as acceptor
                1.3.8.4 isovaleryl-CoA dehydrogenase

Substrates Products

Substrates Products on EC 1.3.8.4 - isovaleryl-CoA dehydrogenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(S)-2-methylbutyryl-CoA + electron-transfer flavoprotein
2-methylcrotonyl-CoA + reduced electron-transfer flavoprotein
show the reaction diagram
-
-
-
?
2-methyl-hexanoyl-CoA + acceptor
2-methylhex-2-enoyl-CoA + reduced acceptor
show the reaction diagram
-
4% relative activity to isovaleryl-CoA
-
?
2-methylbutanoyl-CoA + acceptor
2-methylbut-2-enoyl-CoA + reduced acceptor
show the reaction diagram
-
low activity with the wild-type and mutant L95V/A99V/L103V/L370M/G374A
-
-
?
2-methylpalmitoyl-CoA + acceptor
2-methylhexadec-2-enoyl-CoA + reduced acceptor
show the reaction diagram
butyryl-CoA + 2,6-dichlorophenolindophenol
?
show the reaction diagram
-
high substrate specificity
-
-
?
butyryl-CoA + acceptor
but-2-enoyl-CoA + reduced acceptor
show the reaction diagram
butyryl-CoA + electron-transfer flavoprotein
crotonyl-CoA + reduced electron-transfer flavoprotein
show the reaction diagram
-
-
-
?
hexanoyl-CoA + acceptor
hex-2-enoyl-CoA + reduced acceptor
show the reaction diagram
hexanoyl-CoA + electron-transfer flavoprotein
hex-2-enoyl-CoA + reduced electron-transfer flavoprotein
show the reaction diagram
-
-
-
?
isobutyryl-CoA + acceptor
2-methylpropanoyl-CoA + reduced acceptor
show the reaction diagram
isovaleryl-CoA + 2,6-dichlorophenolindophenol
?
show the reaction diagram
-
high substrate specificity
-
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
show the reaction diagram
isovaleryl-CoA + electron transfer protein
3-methylcrotonoyl-CoA + reduced electron transfer protein
show the reaction diagram
isovaleryl-CoA + electron transfer protein
3-methylcrotonyl-CoA + reduced electron transfer protein
show the reaction diagram
isovaleryl-CoA + electron-transfer flavoprotein
3-methylcrotonyl-CoA + reduced electron-transfer flavoprotein
show the reaction diagram
-
-
-
?
isovaleryl-CoA + FAD
3-methylcrotonyl-CoA + FADH2
show the reaction diagram
isovaleryl-CoA + phenazine methosulfate
3-methylcrotonyl-CoA + reduced phenazine methosulfate
show the reaction diagram
n-valeryl-CoA + acceptor
pent-2-enoyl-CoA + reduced acceptor
show the reaction diagram
octanoyl-CoA + acceptor
oct-2-enoyl-CoA + reduced acceptor
show the reaction diagram
valeryl-CoA + acceptor
pent-2-enoyl-CoA + reduced acceptor
show the reaction diagram
additional information
?
-