1.3.8.4: isovaleryl-CoA dehydrogenase

This is an abbreviated version!
For detailed information about isovaleryl-CoA dehydrogenase, go to the full flat file.

Word Map on EC 1.3.8.4

Reaction

isovaleryl-CoA
+
electron-transfer flavoprotein
=
3-methylcrotonyl-CoA
+
reduced electron-transfer flavoprotein

Synonyms

acyl-CoA dehydrogenase, i3VD, iso(3)valeryl-CoA dehydrogenase, isovaleric-CoA dehydrogenase, isovaleroyl-coenzyme A dehydrogenase, isovaleryl-coenzyme A dehydrogenase, IVD, IVDH, LiuA, SBCAD, short/branched chain acyl-CoA dehydrogenase

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.8 With a flavin as acceptor
                1.3.8.4 isovaleryl-CoA dehydrogenase

Cloned

Cloned on EC 1.3.8.4 - isovaleryl-CoA dehydrogenase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
at the amino acid level, pea enzyme is 60% similar to human and rat enzyme
-
cDNA modified at its 5'-end coding region to enhance expression in Escherichia coli
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clone obtained from the screening of an Arabidopsis whole plant library cDNA library
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cloning of cDNAs of two distinct potato enzyme genes, clone obtained from the screening of a potato flower cDNA library
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DNA and amino acid sequence determination and comparison, expression in Escherichia coli strain BL21(DE3)
expressed in Escherichia coli
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expression in Escherichia coli
expression in pea seedlings
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expression of liuA in Escherichia coli strain Rosetta 2 (DE3), subcloning in Escherichia coli strain JM109
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expression of normal and mutant enzymes in Escherichia coli
expression of wild-type and mutant enzyme in Escherichia coli
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expression of wild-type and mutants in Escherichia coli
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expression of wild-type and mutants in Escherichia coli strain JM105
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gene ivdh, expression analysis and metabolic profiling
IVD gene, DNA and amino acid sequence deteremination and analysis, alignment of BmIVD with all 11 human acyl-CoA dehydrogenase family members, overview. Expression of wild-type BmIVD and sku-type BmIVD in Spodoptera frugiperda Sf9 cells via transfection with baculovrius
the gene spans approximately 17 kb and contains 12 coding exons organized identically to the human gene, amino acid sequences are 95.8 and 89.6% identical to that of the rat and human sequences, respectively
via immunopurification of enzyme mRNA from polyribosomes for preparation of an enriched cDNA library in pBR322 plasmid, and screening with synthetic oligonucleotide probes corresponding to the amino-terminal sequence of purified rat enzyme protein
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