1.3.8.2: 4,4'-diapophytoene desaturase (4,4'-diapolycopene-forming)
This is an abbreviated version!
For detailed information about 4,4'-diapophytoene desaturase (4,4'-diapolycopene-forming), go to the full flat file.
Word Map on EC 1.3.8.2
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1.3.8.2
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carotenoid
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aureus
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mrsas
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staphyloxanthin
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4,4'-diaponeurosporene
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methicillin-resistant
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farnesyl
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newman
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antivirulence
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dehydrogenate
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shields
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orange
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submicromolar
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carnosus
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plantarum
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desaturases
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carotene
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lactobacillus
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desaturation
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pyrophosphate
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glycosyltransferase
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naftifine
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medicine
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drug development
- 1.3.8.2
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carotenoid
- aureus
-
mrsas
- staphyloxanthin
- 4,4'-diaponeurosporene
-
methicillin-resistant
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farnesyl
- newman
-
antivirulence
-
dehydrogenate
-
shields
-
orange
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submicromolar
- carnosus
- plantarum
-
desaturases
- carotene
- lactobacillus
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desaturation
- pyrophosphate
- glycosyltransferase
- naftifine
- medicine
- drug development
Reaction
Synonyms
CrtN, CrtQa, dehydrosqualene desaturase, diapophytoene desaturase
ECTree
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Inhibitors
Inhibitors on EC 1.3.8.2 - 4,4'-diapophytoene desaturase (4,4'-diapolycopene-forming)
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(2E)-3-[2-fluoro-4-(trifluoromethyl)phenyl]-2-methylprop-2-en-1-ol
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(2E)-N-ethyl-N-[(1H-indol-7-yl)methyl]-3-[4-(trifluoromethyl)phenyl]prop-2-en-1-amine
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(2E)-N-[(1H-indol-7-yl)methyl]-3-(3-methoxyphenyl)-N-methylprop-2-en-1-amine
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(2E)-N-[(1H-indol-7-yl)methyl]-3-[4-(trifluoromethyl)phenyl]prop-2-en-1-amine
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(2E)-N-[(1H-indol-7-yl)methyl]-N-(propan-2-yl)-3-[4-(trifluoromethyl)phenyl]prop-2-en-1-amine
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(2E)-N-[(2H-1,3-benzodioxol-5-yl)methyl]-N-methyl-3-(4-methylphenyl)prop-2-en-1-amine
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(2E,4E)-5-(2-fluoro-4-(trifluoromethyl)phenyl)penta-2,4-dien-1-ol
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(2E,4E)-5-([1,1'-biphenyl]-4-yl)-N-(benzofuran-3-ylmethyl)-N-methylpenta-2,4-dien-1-amine
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(2E,4E)-N-((1H-indol-7-yl)methyl)-5-([1,1'-biphenyl]-4-yl)-N-methylpenta-2,4-dien-1-amine
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(2E,4E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(2-fluoro-4-(trifluoromethyl)phenyl)-N-methylpenta-2,4-dien-1-amine
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(E)-3-([1,1'-biphenyl]-4-yl)-N-(benzofuran-3-ylmethyl)-N,2-dimethylprop-2-en-1-amine
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(E)-3-([1,1'-biphenyl]-4-yl)-N-(benzofuran-3-ylmethyl)-N-methylprop-2-en-1-amine
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(E)-3-([1,1'-biphenyl]-4-yl)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-methylprop-2-en-1-amine
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(E)-4-(3-(((1H-indol-7-yl)methyl)(methyl)amino)prop-1-en-1-yl)benzonitrile
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(E)-4-(3-((benzofuran-3-ylmethyl)(methyl)amino)prop-1-en-1-yl)benzonitrile
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(E)-4-(3-((benzo[d][1,3]dioxol-5-ylmethyl)(methyl)amino)prop-1-en-1-yl)benzonitrile
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(E)-4-([1,1'-biphenyl]-4-yl)-N-(benzofuran-3-ylmethyl)-N-methylbut-3-en-1-amine
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(E)-methyl 4-(3-((benzo[d][1,3]dioxol-5-ylmethyl)(methyl)amino)prop-1-en-1-yl)benzoate
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(E)-N-((1H-indol-2-yl)methyl)-N-methyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine
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(E)-N-((1H-indol-3-yl)methyl)-N-methyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine
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(E)-N-((1H-indol-4-yl)methyl)-N-methyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine
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(E)-N-((1H-indol-5-yl)methyl)-N-methyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine
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(E)-N-((1H-indol-6-yl)methyl)-N-methyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-3-(2,4-dichlorophenyl)-N-methylprop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-3-(2-chlorophenyl)-N-methylprop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-3-(2-fluoro-4-(trifluoromethyl)-phenyl)-N-methylprop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-3-(2-fluoro-4-methoxyphenyl)-N-methylprop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-3-(2-fluorophenyl)-N-methylprop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-3-(2-methoxyphenyl)-N-methylprop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-3-(3-chlorophenyl)-N-methylprop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-3-(3-fluoro-4-(trifluoromethyl)-phenyl)-N-methylprop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-3-(3-fluoro-4-methoxyphenyl)-N-methylprop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-3-(3-fluorophenyl)-N-methylprop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-3-(4-(difluoromethyl)phenyl)-N-methylprop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-3-(4-(tert-butyl)phenyl)-N-methylprop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-3-(4-bromophenyl)-N-methylprop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-3-(4-chlorophenyl)-N-methylprop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-3-(4-ethoxyphenyl)-N-methylprop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-3-(4-fluorophenyl)-N-methylprop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-3-(4-methoxyphenyl)-N-methylprop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-3-(furan-2-yl)-N-methylprop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-3-([1,1'-biphenyl]-4-yl)-N,2-dimethylprop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-3-([1,1'-biphenyl]-4-yl)-N-methylprop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-3-cyclohexyl-N-methylprop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-3-cyclopentyl-N-methylprop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-4-([1,1'-biphenyl]-4-yl)-N-methylbut-3-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(2-(trifluoromethyl)phenyl)prop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(2-nitrophenyl)-prop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(3-(trifluoromethyl)phenyl)prop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(3-nitrophenyl)-prop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(4-nitrophenyl)-prop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(m-tolyl)prop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(naphthalen-1-yl)-prop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(naphthalen-2-yl)-prop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(o-tolyl)prop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(p-tolyl)prop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(thiophen-2-yl)-prop-2-en-1-amine
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(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-phenylprop-2-en-1-amine
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(E)-N-((3a,7a-dihydrobenzofuran-3-yl)methyl)-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine
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(E)-N-((3a,7a-dihydrobenzofuran-3-yl)methyl)-N-ethyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine
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(E)-N-((3a,7a-dihydrobenzofuran-3-yl)methyl)-N-isopropyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine
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(E)-N-(benzofuran-2-ylmethyl)-N-methyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-3-(2,4-dichlorophenyl)-Nmethylprop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-3-(2-chlorophenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-3-(2-fluoro-4-(trifluoromethyl)phenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-3-(2-fluoro-4-methoxyphenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-3-(2-fluorophenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-3-(2-methoxyphenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-3-(3-chlorophenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-3-(3-fluoro-4-(trifluoromethyl)phenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-3-(3-fluoro-4-methoxyphenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-3-(3-fluorophenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-3-(3-methoxyphenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-3-(4-(difluoromethyl)phenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-3-(4-(tert-butyl)phenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-3-(4-bromophenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-3-(4-chlorophenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-3-(4-ethoxyphenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-3-(4-fluorophenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-3-(furan-2-yl)-N-methylprop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-3-cyclohexyl-N-methylprop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-3-cyclohexyl-N-methyprop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-3-cyclopentyl-N-methylprop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-3-cyclopentyl-N-methyprop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(2-(trifluoromethyl)phenyl)prop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(2-nitrophenyl)-prop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(3-(trifluoromethyl)phenyl)prop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(3-nitrophenyl)-prop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(4-nitrophenyl)-prop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(m-tolyl)prop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(naphthalen-1-yl)prop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(naphthalen-2-yl)prop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(o-tolyl)prop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(p-tolyl)prop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(thiophen-2-yl)-prop-2-en-1-amine
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(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-phenylprop-2-en-1-amine
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(E)-N-(benzofuran-7-ylmethyl)-N-methyl-3-(4-(trifluoromethyl)-phenyl)prop-2-en-1-amine
inhibits the pigment production of S. aureus Newman and three MRSA strains, without any impact on the survival of four strains. Compound shows good oral bioavailability and safety profiles. IC50 value for growth of Staphylococcus aureus 3.9 nM
(E)-N-(benzo[b]thiophen-2-ylmethyl)-N-methyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine
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(E)-N-(benzo[b]thiophen-3-ylmethyl)-N-methyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(2,4-dichlorophenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(2-chlorophenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(2-fluoro-4-(trifluoromethyl)phenyl)-N,2-dimethylprop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(2-fluoro-4-(trifluoromethyl)phenyl)-N-isopropylprop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(2-fluoro-4-(trifluoromethyl)phenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(2-fluoro-4-(trifluoromethyl)phenyl)prop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(2-fluoro-4-methoxyphenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(2-fluorophenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(2-methoxyphenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(3-chlorophenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(3-fluoro-4-(trifluoromethyl)phenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(3-fluoro-4-methoxyphenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(3-fluorophenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(3-methoxyphenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(4-(difluoromethyl)phenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(4-(tert-butyl)phenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(4-bromophenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(4-chlorophenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(4-ethoxyphenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(4-fluorophenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(4-methoxyphenyl)-N-methylprop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(furan-2-yl)-N-methylprop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-cyclohexyl-N-methylprop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-cyclopentyl-N-methylprop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-ethyl-3-(2-fluoro-4-(trifluoromethyl)phenyl)prop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-methyl-3-(2-(trifluoromethyl)phenyl)prop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-methyl-3-(3-(trifluoromethyl)phenyl)prop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-methyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-methyl-3-(4-nitrophenyl)prop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-methyl-3-(m-tolyl)prop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-methyl-3-(naphthalen-1-yl)prop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-methyl-3-(naphthalen-2-yl)prop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-methyl-3-(o-tolyl)prop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-methyl-3-(thiophen-2-yl)prop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-methyl-3-phenylprop-2-en-1-amine
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(E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-methylbut-2-en-1-amine
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1-(benzo[d][1,3]dioxol-5-yl)-N-(((1R,2R)-2-(2-fluoro-4-(trifluoromethyl)phenyl)cyclopropyl)methyl)-N-methylmethanamine
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3-([1,1'-biphenyl]-4-yl)-N-(benzofuran-3-ylmethyl)-N-methylprop-2-yn-1-amine
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3-([1,1'-biphenyl]-4-yl)-N-(benzofuran-3-ylmethyl)-N-methylpropan-1-amine
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ethyl (2E,4E)-5-(2-fluoro-4-(trifluoromethyl)phenyl)penta-2,4-dienoate
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ethyl (E)-3-(2-fluoro-4-(trifluoromethyl)phenyl)-2-methylacrylate
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methyl (E)-4-(3-(((1H-indol-7-yl)methyl)(methyl)amino)prop-1-en-1-yl)benzoate
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methyl (E)-4-(3-((benzofuran-3-ylmethyl)(methyl)amino)-prop-1-en-1-yl)benzoate
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methyl(E)-4-(3-((benzofuran-3-ylmethyl)(methyl)amino)-prop-1-en-1-yl)benzoate
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N-((1H-indol-7-yl)methyl)-3-([1,1'-biphenyl]-4-yl)-N-methylprop-2-yn-1-amine
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N-((1H-indol-7-yl)methyl)-3-([1,1'-biphenyl]-4-yl)-N-methylpropan-1-amine
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N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(2-fluoro-4-(trifluoromethyl)phenyl)-N-methylprop-2-yn-1-amine
vivo effects of (2E,4E)-N-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(2-fluoro-4-(trifluoromethyl)phenyl)-N-methylpenta-2,4-dien-1-amine on attenuating the virulence of Newman, Mu50 and NRS271
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N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(2-fluoro-4-(trifluoromethyl)phenyl)-N-methylpropan-1-amine
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naftifine
blocks biosynthesis of carotenoid pigment at nanomolar concentrations by competitive inhibition of diapophytoene desaturase CrtN. Naftifine attenuates the virulence of strain Newman and of a variety of clinical Staphylocuus aureus isolates, in mouse infection models
piperonyl derivatives as diapophytoene desaturase inhibitors for the treatment of methicillin-, vancomycin- and linezolid-resistant Staphylococcus aureus infections, cytotoxicity analysis using Hep-G2 and HEK-293T cells and BALB-C mice, in vitro pigment inhibitory activities, overview
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additional information
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piperonyl derivatives as diapophytoene desaturase inhibitors for the treatment of methicillin-, vancomycin- and linezolid-resistant Staphylococcus aureus infections, cytotoxicity analysis using Hep-G2 and HEK-293T cells and BALB-C mice, in vitro pigment inhibitory activities, overview
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additional information
synthesis of a series of CrtN inhibitors with other scaffolds, method overview. The compounds show excellent activity against different MRSA in in vitro and in vivo at a lower dosage but also overcome the disadvantages of hERG inhibition. Linezolid and vancomycin, the last-resort antimicrobial agents, are introduced as positive control drugs into a murine model of Staphylococcus aureus abscess formation to evaluate the effectiveness of the analogues. Diapophytoene desaturase inhibitors for the treatment of methicillin-, vancomycin- and linezolid-resistant Staphylococcus aureus infections, cytotoxicity analysis using Hep-G2 and HEK-293T cells and BALB-C mice, in vitro pigment inhibitory activities, in vivo cytotoxicity IC50 values and pigment inhibition activity IC50 values, overview
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