1.3.5.3: protoporphyrinogen IX dehydrogenase (quinone)
This is an abbreviated version!
For detailed information about protoporphyrinogen IX dehydrogenase (quinone), go to the full flat file.
Reaction
Synonyms
HemG, HemG protein, PPO, PPOX, PPX, PPX1, protogen oxidase, protoporphyrinogen IX dehydrogenase (menaquinone), protoporphyrinogen IX oxidase
ECTree
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Engineering
Engineering on EC 1.3.5.3 - protoporphyrinogen IX dehydrogenase (quinone)
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additional information
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Escherichia coli strain SASX38 lacks functional protoporphyrinogen IX dehydrogenase activity and is reported to be deficient in HemG. Sequence analysis of the SASX38 hemG gene reveals a deletion from nucleotide 152 to 470. This results in a predicted HemG protein that remains in frame but lacks 106 internal amino acids, including the long chain insert loop
additional information
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four electron transport chains from HemG via diverse quinones to cytochrome bo3, cytochrome bd, nitrate reductase, and fumarate reductase were reconstituted in vitro from purified components, overview