1.3.5.2: dihydroorotate dehydrogenase (quinone)

This is an abbreviated version!
For detailed information about dihydroorotate dehydrogenase (quinone), go to the full flat file.

Word Map on EC 1.3.5.2

Reaction

(S)-dihydroorotate
+
a quinone
=
Orotate
+
a quinol

Synonyms

class 2 dihydroorotate dehydrogenases, DHO-DH, DHOD, DHODase, DHODH, HsDHODH, L-5,6-dihydroorotate:ubiquinone exidoreductase, PfDHODH

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.5 With a quinone or related compound as acceptor
                1.3.5.2 dihydroorotate dehydrogenase (quinone)

Systematic Name

Systematic Name on EC 1.3.5.2 - dihydroorotate dehydrogenase (quinone)

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
SYSTEMATIC NAME
IUBMB Comments
(S)-dihydroorotate:quinone oxidoreductase
This Class 2 dihydroorotate dehydrogenase enzyme contains FMN [4]. The enzyme is found in eukaryotes in the mitochondrial membrane, in cyanobacteria, and in some Gram-negative and Gram-positive bacteria associated with the cytoplasmic membrane [2,5,6]. The reaction is the only redox reaction in the de-novo biosynthesis of pyrimidine nucleotides [2,4]. The best quinone electron acceptors for the enzyme from bovine liver are ubiquinone-6 and ubiquinone-7, although simple quinones, such as benzoquinone, can also act as acceptor at lower rates [2]. Methyl-, ethyl-, tert-butyl and benzyl (S)-dihydroorotates are also substrates, but methyl esters of (S)-1-methyl and (S)-3-methyl and (S)-1,3-dimethyldihydroorotates are not [2]. Class 1 dihydroorotate dehydrogenases use either fumarate (EC 1.3.98.1), NAD+ (EC 1.3.1.14) or NADP+ (EC 1.3.1.15) as electron acceptor.