1.3.5.2: dihydroorotate dehydrogenase (quinone)

This is an abbreviated version!
For detailed information about dihydroorotate dehydrogenase (quinone), go to the full flat file.

Word Map on EC 1.3.5.2

Reaction

(S)-dihydroorotate
+
a quinone
=
Orotate
+
a quinol

Synonyms

class 2 dihydroorotate dehydrogenases, DHO-DH, DHOD, DHODase, DHODH, HsDHODH, L-5,6-dihydroorotate:ubiquinone exidoreductase, PfDHODH

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.5 With a quinone or related compound as acceptor
                1.3.5.2 dihydroorotate dehydrogenase (quinone)

KM Value

KM Value on EC 1.3.5.2 - dihydroorotate dehydrogenase (quinone)

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.06 - 0.265
(S)-dihydroorotate
0.028
1,4-Naphthoquinone
-
pH 8.0, 30°C
0.099
2,3-dimethoxy-5-methyl-1,4-benzoquinone
-
pH 8.0, 30°C
0.132
2,5-dimethyl-p-benzoquinone
-
pH 8.0, 30°C
0.0146
2,6-dichlorophenolindophenol
-
S175C mutant
0.0058
2,6-dihydrophenolindophenol
-
-
7.8 - 48
coenzyme Q1
0.0011 - 0.022
coenzyme Q6
0.0013
coenzyme Q7
-
cosubstrate benzyl-S-dihydroorotate
8.8 - 53
coenzyme QD
0.0095
decyclubiquinone
-
recombinant enzyme
0.0065 - 0.341
decylubiquinone
0.004 - 0.122
dihydroorotate
0.015 - 0.123
L-dihydroorotate
0.184
menadione
-
-
0.0154 - 0.1542
methyl dihydroorotate
0.0019
methyl-S-dihydroorotate
-
-
0.0062 - 0.115
S-dihydroorotate
0.007 - 0.062
ubiquinone
0.04 - 0.075
ubiquinone-0
0.051
ubiquinone-30
-
pH 8.0, 30°C
0.035
ubiquinone-4
pH 8.0, 25°C, cosubstrate L-dihydroorotate, N-terminally truncated protein
0.01 - 0.027
ubiquinone-50
0.0225 - 0.062
ubiquinone-6
additional information
additional information
-
relative Km-values for wild-type and mutants listed for (S)-dihydroorotate and ubiquinone-6
-