1.3.5.2: dihydroorotate dehydrogenase (quinone)

This is an abbreviated version!
For detailed information about dihydroorotate dehydrogenase (quinone), go to the full flat file.

Word Map on EC 1.3.5.2

Reaction

(S)-dihydroorotate
+
a quinone
=
Orotate
+
a quinol

Synonyms

class 2 dihydroorotate dehydrogenases, DHO-DH, DHOD, DHODase, DHODH, HsDHODH, L-5,6-dihydroorotate:ubiquinone exidoreductase, PfDHODH

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.5 With a quinone or related compound as acceptor
                1.3.5.2 dihydroorotate dehydrogenase (quinone)

KI Value

KI Value on EC 1.3.5.2 - dihydroorotate dehydrogenase (quinone)

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000418 - 0.001565
(S)-dihydroorotate
0.00005 - 0.0604
2-cyano-3-(9-ethyl-9H-carbazol-3-ylamino)acrylic acid ethyl ester
0.4
2-cyano-3-cyclopropyl-3-hydroxy-N-[4'-(nitro)phenyl]-propenamide
pH 8.0, 25C, varied substrate QD, N-terminally truncated protein
0.0002 - 0.001
2-hydroxyethylidene-cyanoacetic acid 4-trifluoromethyl anilide
0.16 - 0.25
3-hydroxy-2-(3,3-dichloroallyl)-1,4-naphthoquinone
0.0244
5-aminoorotate
-
-
0.1408
5-bromoorotate
-
-
0.0151
5-Fluoroorotate
-
-
0.2246
5-iodoorotate
-
-
0.1185
5-Methylorotate
-
-
0.000698 - 0.015
atovaquone
0.092
Barbiturate
-
-
0.003
Barbituric acid
-
-
0.0000232 - 0.0000265
brequinar sodium
0.000174 - 0.000333
decylubiquinone
0.00001 - 0.000067
dichloro-allyllawsone
0.000061 - 0.000618
Lapachol
0.049 - 0.5
Lawsone
0.0134 - 0.0388
Orotate
0.005
Orotic acid
-
competitive to dihydroorotate
0.059 - 0.086
redoxal