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1.3.5.2: dihydroorotate dehydrogenase (quinone)

This is an abbreviated version!
For detailed information about dihydroorotate dehydrogenase (quinone), go to the full flat file.

Word Map on EC 1.3.5.2

Reaction

(S)-dihydroorotate
+
a quinone
=
Orotate
 +
a quinol

Synonyms

class 2 dihydroorotate dehydrogenases, DHO-DH, DHOD, DHODase, DHODH, dihydroorotate dehydrogenase, EC 1.3.99.11, ETH_00004975, hDHODH, HsDHODH, L-5,6-dihydroorotate:ubiquinone exidoreductase, PfDHODH

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.5 With a quinone or related compound as acceptor
                1.3.5.2 dihydroorotate dehydrogenase (quinone)

Activating Compound

Activating Compound on EC 1.3.5.2 - dihydroorotate dehydrogenase (quinone)

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-(4-biphenylylcarbamoyl)-2-benzoic acid
i.e. MD 129, 0.5 mM, 103% of initial activity
-
alloxan
0.5 mM, 112% of initial activity
atovaquone
0.5 mM, 127% of initial activity
NSC 277965
0.5 mM, 130% of initial activity
-
NSC 71097
0.5 mM, 129% of initial activity
-
oxygen
seems to promote very low DHODH activity
additional information
-