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1.3.5.1: succinate dehydrogenase

This is an abbreviated version!
For detailed information about succinate dehydrogenase, go to the full flat file.

Word Map on EC 1.3.5.1

Reaction

succinate
+
a quinone
=
fumarate
 +
a quinol

Synonyms

8-methylmenaquinol:fumarate reductase, AaSdhB, bacterial succinate:quinone oxidoreductase flavoprotein, complex II, Complex II homolog, complex II of the respiratory chain, complex II succinate:ubiquinone oxidoreductase, DCPIP oxidoreductase, dehydrogenase, succinate, dehydrogenase/complex II, EC 1.3.5.4, EC 1.3.99.1, Fcc3, fdrB, FL cyt, Flavocytochrome c3, FRD, FrdA, FRdABCD, FrdC, FRdCAB, FrdD, fumarate reductase, fumarate reductase complex, fumaric hydrogenase, Ifc3, Iron(III)-induced flavocytochrome C3, iron-sulfur subunit of succinate dehydrogenase, menaquinol-1 fumarate reductase, menaquinol-fumarate oxidoreductase, menaquinol:fumarate oxidoreductase, methylmenaquinol:fumarate reductase, MFR, MFR complex, MfrA, MfrB, mitochondrial complex II, mitochondrial succinate dehydrogenase, mitochondrial succinate:ubiquinone oxidoreductase, More, mQFR, MSMEG_0416, MSMEG_0417, MSMEG_0418, MSMEG_0419, MSMEG_0420, MSMEG_1669, MSMEG_1670, MSMEG_1671, MSMEG_1672, non-classical succinate:quinone reductase, QFR, quinol-fumarate reductase, quinol:fumarate reductase, SDG, SDG-1, SDG-2, SDH, SDH1, SDH2, SDH2-1, SDH2-2, SDH3, SDH4, SdhA, sdhABE, SDHB, SdhC, sdhCAB, SdhCDAB, SdhD, SDISP, SQR, succinate dehydrogenase, succinate dehydrogenase (caldariellaquinone), succinate dehydrogenase (quinone), succinate dehydrogenase B, succinate dehydrogenase complex, succinate dehydrogenase flavoprotein subunit Sdh1p, succinate dehydrogenase iron-sulfur protein, succinate dehydrogenase iron-sulphur protein, succinate dehydrogenase subunit B, succinate oxidoreductase, succinate-2,6-dichlorophenolindophenol oxidoreductase, succinate-coenzyme Q reductase, succinate-quinone oxidoreductase, succinate-quinone reductase, succinate-ubiquinone oxidoreductase, succinate:caldariellaquinone oxidoreductase, succinate:menaquinone 7-reductase, succinate:menaquinone oxidoreductase, succinate:menaquinone reductase, succinate:MK reductase, succinate:quinone oxidoreductase, succinate:quinone reductase, succinate:quinone reductases, succinate:ubiquinone oxidoreductase, succinate:ubiquinone reductase, succinic acid dehydrogenase, succinic dehydrogenase, succinodehydrogenase, succinyl dehydrogenase, Tneu_0423

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.5 With a quinone or related compound as acceptor
                1.3.5.1 succinate dehydrogenase

Activating Compound

Activating Compound on EC 1.3.5.1 - succinate dehydrogenase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2,4-dinitrophenol
-
activation
3-oxobutyrate
-
-
5-n-undecyl-6-hydroxy-4,7-dioxobenzothiazole
-
slightly activates
alpha-glycerophosphate
-
-
antimycin A
-
activates
aripiprazole
-
chronic administration of the antipsychotic agent, increases SDH activity in the prefrontal cortex at high doses of 20 mg/kg body weight
cardiolipin
-
stimulation in presence of detergent
Chaotropic anions
-
activation
-
cytochrome b-558
-
diphosphate
-
activation
dithiothreitol
-
required for activity
flavin
-
the 66000 Da subunit is the flavoprotein subunit containing a covalently bound flavin
FMNH2
-
activation
fumarate
-
activation
IDP
-
activation
Iron-sulfur cluster
-
the cluster is fixed by cysteines of two cysteine-rich CCG domain sequence motifs (CX31-39CCX35-36CXXC) of subunit Sdh of the Sulfolobus solfataricus succinate:quinone reductase
isocitrate
-
-
ITP
-
activation
KCN
-
activation at 6.7 mM up to 10 mM when both alternative pathways to oxygen are inhibited
malonate
medium-chain triglycerides ketogenic diet
-
cytochemical investigation of SDH activity in cardiomyocytes of late adult rats fed for 8 weeks with a medium-chain triglycerides ketogenic diet is performed. Young, age-matched and old animals fed with a standard chow are used as controls. It is shown that the medium-chain triglycerides ketogenic diet intake partially recovers age-related decrease of SDH activity and increases the myocardial area occupied by metabolically active mitochondria. These effects might counteract metabolic alterations leading to apoptosis-induced myocardial atrophy and failure during aging
-
menaquinone-9(2H)
-
-
Mucidin
-
activates
Na2SO4
-
activation
NaN3
-
activation
phenazine methosulfate
-
-
phosphate
-
activation
Phospholipids
-
activation
protein SDHA F2
-
the factor is needed for assembly and activity of SDH and also for normal root elongation, sequence diversity and conservation of SDHA F2 across kingdoms, phylogenetic analysis, overview
-
reduced ubiquinone-10
-
activation
Sodium citrate
-
activation
succinate
succinyl coenzyme A
-
activation
Tcm62
-
importance in SDH assembly
-
additional information
-