1.3.3.5: bilirubin oxidase
This is an abbreviated version!
For detailed information about bilirubin oxidase, go to the full flat file.
Word Map on EC 1.3.3.5
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1.3.3.5
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electrode
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oxidases
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biofuel
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cathode
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ceruloplasmin
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myrothecium
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anode
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laccases
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verrucaria
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biocathode
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ferroxidase
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trinuclear
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abts
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laccase-like
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dioxygen
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bioanode
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electrocatalytic
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bioelectrocatalytic
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2,6-dimethoxyphenol
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biliverdin
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cuprous
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multi-copper
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syringaldazine
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copa
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copper-binding
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four-electron
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mniii
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self-powered
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aceruloplasminemia
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hephaestin
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p-phenylenediamine
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manganeseii
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bioelectrodes
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open-circuit
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membrane-less
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cupredoxins
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analysis
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electrocatalysts
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manganese-oxidizing
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methionine-rich
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diazo
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biodevice
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energy production
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medicine
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diagnostics
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biotechnology
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synthesis
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environmental protection
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industry
- 1.3.3.5
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electrode
- oxidases
-
biofuel
-
cathode
- ceruloplasmin
- myrothecium
-
anode
- laccases
- verrucaria
-
biocathode
- ferroxidase
-
trinuclear
- abts
-
laccase-like
- dioxygen
-
bioanode
-
electrocatalytic
-
bioelectrocatalytic
- 2,6-dimethoxyphenol
- biliverdin
-
cuprous
-
multi-copper
- syringaldazine
- copa
-
copper-binding
-
four-electron
-
mniii
-
self-powered
-
aceruloplasminemia
- hephaestin
- p-phenylenediamine
-
manganeseii
-
bioelectrodes
-
open-circuit
-
membrane-less
- cupredoxins
- analysis
-
electrocatalysts
-
manganese-oxidizing
-
methionine-rich
-
diazo
-
biodevice
- energy production
- medicine
- diagnostics
- biotechnology
- synthesis
- environmental protection
- industry
Reaction
2 bilirubin + = 2 biliverdin + 2 H2O
Synonyms
bilirubin oxidase, bilirubin oxidase M-1, bilirubin:oxygen oxidoreductase, blue Cu enzyme, BOD, BODx, BOX, BPUM_0542, copper oxidase, CotA, MCO, multicopper oxidase, MvBO, MvBOD, oxidase, bilirubin
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Application
Application on EC 1.3.3.5 - bilirubin oxidase
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analysis
biofuel production
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the enzyme is used in a biofuel cell comprising enzymeless anode consisting of 0.2 mM braided gold wire modified with colloidal platinum and bilirubin oxidase-modified gold-coated Buckypaper biocathode
biotechnology
diagnostics
energy production
environmental protection
industry
medicine
synthesis
additional information
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enzyme activity in serum bilirubin assays can be monitored by capillary electrophoresis
analysis
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immobilized onto aminopropyl and arylamine glass beads to form an enzyme bioreactor
analysis
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sandwich-type enzyme-amplified amperometric detection of DNA with ambient O2 as the substrate at neutral pH in the presence of chloride
analysis
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application of polyammonium cations to enzyme-immobilized electrode: application as enzyme stabilizer for bilirubin oxidase
analysis
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application of poly[oxyethylene(dimethylimino)propyl-(dimethylimino)ethylene] as enzyme stabilizer for bilirubin oxidase immobilized electrode
analysis
BOD has attracted considerable attention as an enzymatic catalyst for the cathode of biofuel cells that work under neutral conditions
analysis
the ability to perform the oxygen reduction reaction under physiological conditions is the most interesting feature of the enzyme bilirubin oxidase in terms of the design of biocathodes for biofuel cell applications. The enzyme is commonly immobilized on a solid carrier to achieve the highest biocatalytic activity, stability, selectivity, and reusability. Optimization of the application of immobilized enzyme for direct electrocatalytic reduction of O2
analysis
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BOD has attracted considerable attention as an enzymatic catalyst for the cathode of biofuel cells that work under neutral conditions
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the enzyme functions effectively as the biocathode of a H2/O2 biofuel cell. It is immmobilized as a multiple layer in a cationic polymer (poly-L-lysine) matrix on an electrode surface. The BOD-modified electrode catalyzes four-electron reduction of O2 to water without any mediator, to produce a diffusion-controlled voltammogram for the O2 reduction in a quiescent solution. Construction of such a multiple enzyme layer is useful for increasing the current density even in direct electron transfer-type bioelectrocatalysis
biotechnology
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the wired" enzyme is superior to pure platinum as a electrocatalyst of the four-electron electroreduction of O2 to water. The "wired" bilirubin oxidase-coated carbon cathode operates for more than 1 week at 37°C in a glucose-containing physiological buffer solution. Key application would be in a glucose-O2 biofuel cell. The cathode is short-lived in serum, losing its electrocatalytic activity in a few hours. The damaging serum component is a product of the reaction of urate and dissolved oxygen. Exclusion of urate, by application of Nafion(TM) film in the cathode, improves the stability in serum
BOD is used for diagnostic analysis of bilirubin in serum
diagnostics
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the BOD activity catalyzing the oxidation of bilirubin to biliverdin can be used for the diagnosis of jaundice and hyperbilirubinemia
diagnostics
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BOD is used for diagnostic analysis of bilirubin in serum
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the BOD from Bacillus pumilus is an attractive candidate for application in biofuel cells and biosensors showing high activity at neutral pH and high tolerance towards NaCl
energy production
design of a bioanode that directly utilizes starch as a fuel in an enzymatic biofuel cell. The enzymatic fuel cell is based on three enzymes (alpha-amylase, glucoamylase and glucose oxidase). The carbon paste electrode containing these three enzymes and tetrathiafulvalene can both saccharize and oxidize starchy biomass. In cyclic voltammetry, catalytic currents are successfully observed with both glucose and starchy white rice used as a substrate. A membraneless white rice/O2 biofuel cell is assembled and the electrochemical performance is evaluated. The three enzyme based electrode is used as a bioanode and an immobilized bilirubin oxidase (derived from Myrothecium verrucaria) electrode is used as a biocathode. The biofuel cell delivers an open circuit voltage of 0.522 V and power density of up to 0.099 mW/cm
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BOX can be used to decolorize synthetic dyes from effluents, especially for anthraquinonic dyes
environmental protection
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the BOD from Magnaporthe oryzae is efficient in decolorizing textile dyes such as Remazol brilliant Blue R, making it useful for environmentally friendly industrial applications
environmental protection
Pyricularia oryzae ATCC MYA-4617
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the BOD from Magnaporthe oryzae is efficient in decolorizing textile dyes such as Remazol brilliant Blue R, making it useful for environmentally friendly industrial applications
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environmental protection
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BOX can be used to decolorize synthetic dyes from effluents, especially for anthraquinonic dyes
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BOX can be used to decolorize synthetic dyes from effluents, especially for anthraquinonic dyes
industry
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BOX can be used to decolorize synthetic dyes from effluents, especially for anthraquinonic dyes
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medicine
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immobilized bilirubin oxidase reactor could be used for the degradation of bilirubin in neonatal jaundice
medicine
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great potential for use as a diagnostic reagent, can be used for accurate determination of serum bilirubin levels in patients with hepatobiliary disease
medicine
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mutants I402G and C457S are not appropriate for diagnostic purpose due to their much lower enzyme activities compared to the recombinant enzyme
enzymatic oxidative polymerization of dihydroquercetin from Larix sibirica using bilirubin oxidase as a biocatalyst. As compared with the monomer, oligoDHQ demonstrates higher thermal stability and high antioxidant activity
synthesis
mediator-less, direct electro-catalytic reduction of oxygen to water is achieved on spectrographite electrodes modified by physical adsorption of bilirubin oxidases from Myrothecium verrucaria. Bilirubin oxidase (BOD) is the best catalyst for converting oxygen directly to water because of the very low overpotential necessary to catalyze the reaction
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redox potential of the T1 site of BOD is > 650 mV vs. NHE, redox potential of the T2 site is near 390 mV vs. NHE
additional information
redox potential of the T1 site of BOD is close to 670 mV vs. NHE, redox potential of the T2 site is near 390 mV vs. NHE
additional information
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redox potential of the T1 site of BOD is close to 670 mV vs. NHE, redox potential of the T2 site is near 390 mV vs. NHE
additional information
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BODs have a high efficiency of decolorizing compounds such as Trypan blue and Remazol brilliant blue R under mild pH conditions
additional information
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BODs have a high efficiency of decolorizing compounds such as Trypan blue and Remazol brilliant blue R under mild pH conditions
additional information
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BODs have a high efficiency of decolorizing compounds such as Trypan blue and Remazol brilliant blue R under mild pH conditions
additional information
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BODs have a high efficiency of decolorizing compounds such as Trypan blue and Remazol brilliant blue R under mild pH conditions
additional information
BODs have a high efficiency of decolorizing compounds such as Trypan blue and Remazol brilliant blue R under mild pH conditions
additional information
BODs have a high efficiency of decolorizing compounds such as Trypan blue and Remazol brilliant blue R under mild pH conditions
additional information
BODs have a high efficiency of decolorizing compounds such as Trypan blue and Remazol brilliant blue R under mild pH conditions
additional information
BODs have a high efficiency of decolorizing compounds such as Trypan blue and Remazol brilliant blue R under mild pH conditions
additional information
BODs have a high efficiency of decolorizing compounds such as Trypan blue and Remazol brilliant blue R under mild pH conditions
additional information
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the purified bilirubin oxidase in Myrothecium verrucaria strain has potential application in dye effluent decolorization. Extracellular bilirubin oxidase decolorizes indigo carmine, biosorption and biodegradation of the dye is achieved with more than 98% decolorization efficiency after 7 days at 26°C. Additionally, the crude bilirubin oxidase can efficiently decolorize indigo carmine at 30°C to 50°C and pH 5.5-9.5 with dye concentrations of 50-200 mg/ml
additional information
usage of the enzyme for a bilirubin oxidase-based air breathing cathode, evaluation by constant monitoring over 45 days, analysis of effect of electrolyte composition on the cathode oxygen reduction reaction output, and of deactivation of the electrocatalytic activity of the enzyme in phosphate buffer saline solution and in activated sludge. BOx electrochemical response as a function of presence of pollutants, solids and bacteria, overview
additional information
the enzyme is used to decolorize recalcitrant dyes
additional information
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the enzyme is used to decolorize recalcitrant dyes
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additional information
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the purified bilirubin oxidase in Myrothecium verrucaria strain has potential application in dye effluent decolorization. Extracellular bilirubin oxidase decolorizes indigo carmine, biosorption and biodegradation of the dye is achieved with more than 98% decolorization efficiency after 7 days at 26°C. Additionally, the crude bilirubin oxidase can efficiently decolorize indigo carmine at 30°C to 50°C and pH 5.5-9.5 with dye concentrations of 50-200 mg/ml
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