1.3.3.16: oxazoline dehydrogenase
This is an abbreviated version!
For detailed information about oxazoline dehydrogenase, go to the full flat file.
Reaction
Synonyms
artG, azoline oxidase, Cyan7425_0520, cyanobactin oxidase, lynG, MbcC, mcaG, McbB, McbC, McbD, microcin B17 synthase, microcin B17-processing protein McbC, PatG, tenG, ThcOx, thiazoline oxidase, thiazoline oxidase/subtilisin-like protease
ECTree
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General Information
General Information on EC 1.3.3.16 - oxazoline dehydrogenase
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physiological function
during biosynthesis of microcin B17, azole introduction into the microcin B17 precursor requires coordination of the activities of the heterocyclase, which converts Ser and Cys residues into azolines, and the dehydrogenase, which oxidizes the azolines to azoles
physiological function
P23184; P23185; P23186
enzyme is part of microcin B17 synthase. The complex three proteins, McbB, McbC, and McbD, that convert 14 residues into the eight mono- and bisheterocyclic moieties in vitro that confer antibiotic activity on mature microcin B17 via a three-step sequence of cyclization, net dehydration, and subsequent two-electron dehydrogenation
physiological function
the primary sequence of patellamides A and C is encoded on a single ORF that resembles a precursor peptide. This prepatellamide is heterocyclized to form thiazole and oxazoline rings, and the peptide is cleaved to yield the two cyclic patellamides, A and C