1.3.1.96: Botryococcus squalene synthase

This is an abbreviated version!
For detailed information about Botryococcus squalene synthase, go to the full flat file.

Reaction

squalene
+
diphosphate
+
NADP+
=
presqualene diphosphate
+
NADPH
+
H+

Synonyms

squalene synthase, squalene synthase-like 2, SSL-2

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.96 Botryococcus squalene synthase

Natural Substrates Products

Natural Substrates Products on EC 1.3.1.96 - Botryococcus squalene synthase

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
presqualene diphosphate + NADPH + H+
squalene + diphosphate + NADP+
show the reaction diagram
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-
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r
additional information
?
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squalene and botryococcene are branched-chain, triterpene compounds that arise from the head-tohead condensation of two molecules of farnesyl diphosphate to yield 1'-1 and 1'-3 linkages, respectively. Different enzymes are responsible for botryococcene and squalene biosynthesis in the green alga Botryococcus braunii race B. The specificity for the 1'-1 and 1'-3 linkages is controlled by residues in the active sites that can mediate catalytic specificity. Identification of several amino acid positions contributing to the rearrangement of the cyclopropyl intermediate to squalene, The same positions do not appear to be sufficient to account for the cyclopropyl rearrangement to give botryococcene, oerview
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?