1.3.1.96: Botryococcus squalene synthase

This is an abbreviated version!
For detailed information about Botryococcus squalene synthase, go to the full flat file.

Reaction

squalene
+
diphosphate
+
NADP+
=
presqualene diphosphate
+
NADPH
+
H+

Synonyms

squalene synthase, squalene synthase-like 2, SSL-2

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.96 Botryococcus squalene synthase

General Information

General Information on EC 1.3.1.96 - Botryococcus squalene synthase

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
SSL-2 catalyzes the NADPH-dependent biosynthesis of approximately 90% bisfarnesyl ether and 10% squalene
physiological function
squalene and botryococcene are branched-chain, triterpene compounds that arise from the head-tohead condensation of two molecules of farnesyl diphosphate to yield 1'-1 and 1'-3 linkages, respectively
additional information
proposed catalytic cascades for the enzyme-mediated biosynthesis of squalene and botryococcene, and molecular modeling of Botryococcus braunii botryococcene and squalene synthase enzymes, overview. Substrate docking and molecular modeling