1.3.1.92: artemisinic aldehyde DELTA11(13)-reductase

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Reaction

Synonyms

artemisinic aldehyde DELTA11(13) double bond reductase2, artemisinic aldehyde DELTA11(13) double-bond reductase, artemisinic aldehyde DELTA11(13) reductase, Dbr2, double bond reductase 2, double-bond reductase 2

ECTree

     1 Oxidoreductases

         1.3 Acting on the CH-CH group of donors

             1.3.1 With NAD⁺ or NADP⁺ as acceptor

                1.3.1.92 artemisinic aldehyde DELTA11(13)-reductase

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Results	in table
1	Activating Compound
1	AA Sequence
4	Application
8	Cloned(Commentary)
8	Cofactor
6	Expression
4	General Information
5	kcat/KM [mM/s]
5	KM Value [mM]
1	Localization
1	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
14	Organism
3	Pathway
4	PDB ID
1	pH Optimum
2	pH Range
3	Protein Variants
1	Purification (Commentary)
1	Reaction
14	Reference
15	Source Tissue
19	Substrates and Products (Substrate)
17	Synonyms
1	Systematic Name
5	Turnover Number [1/s]

Expression

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Expression on EC 1.3.1.92 - artemisinic aldehyde DELTA11(13)-reductase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

expression levels of farnesyl diphosphate synthase (FPS), cytochrome P450-dependent hydroxylase CYP71AV1, and double bond reductase 2 (DBR2) are increased significantly in plants overexpressing Artemisia annua allene oxide cyclase, AaAOC. The product of AOC is jasmonate, that induces the expression of FPS, CYP71AV1, and DBR2

Artemisia annua

C5H429

746262

methyljasmonate does not induce significant changes in the expression of DBR2

Artemisia annua

C5H429

718204

the enzyme DBR2 is induced by 0.12 mmol/l of cadmium. Appropriate doses of cadmium can increase the concentrations of artemisinic metabolites at a certain time point by upregulating the relative expression levels of key enzyme genes involved in artemisinin biosynthesis, overview

Artemisia annua

C5H429

744971

three jasmonate-responsive transcription factors, ethylene response factor 1, ethylene response factor 2, and octadecanoidresponsive AP2/ERF, all transcriptionally activate the expression of artemisinin biosynthetic genes, such as amorpha-4,11-diene synthase (ADS), CYP71AV1, DBR2, and aldehyde dehydrogenase 1 (ALDH1). Cold stress indirectly activates the DBR2 expression by increasing the amount of jasmonate through upregulation of jasmonate biosynthetic genes (LOX1, LOX2, allene oxide cyclase [AOC], and jasmonate resistant 1 [JAR1]). Levels of artemisinin and related secondary metabolites, such as dihydroartemisinic acid, artemisinin B, and artemisinic acid, are increased in Artemisia annua under cold stress

Artemisia annua

C5H429

744543

treatment for 30 min and 4 h with miconazole induces about four- und fivefold upregulation of the DBR2 gene, respectively

Artemisia annua

C5H429

718204

YABBY5 significantly increases the activity of the promoter of the enzyme

Artemisia annua

-

764774