1.3.1.86: crotonyl-CoA reductase
This is an abbreviated version!
For detailed information about crotonyl-CoA reductase, go to the full flat file.
Word Map on EC 1.3.1.86
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1.3.1.86
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polyketide
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butyryl-coa
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ethylmalonyl-coas
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macrolide
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collinus
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cinnamonensis
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streptomycetes
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monensin
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icl
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acetoacetyl-coa
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straight-chain
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salinomycin
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tylactone
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poly3-hydroxybutyrate
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oil-based
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poly3-hydroxybutyrate-co-3-hydroxyhexanoate
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avermitilis
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tylosin
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fradiae
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mycaminose
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enoyl-coa
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3-hydroxyhexanoate
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isobutyryl-coa
- 1.3.1.86
- polyketide
- butyryl-coa
- ethylmalonyl-coas
-
macrolide
- collinus
- cinnamonensis
- streptomycetes
- monensin
- icl
- acetoacetyl-coa
-
straight-chain
- salinomycin
- tylactone
-
poly3-hydroxybutyrate
-
oil-based
-
poly3-hydroxybutyrate-co-3-hydroxyhexanoate
- avermitilis
- tylosin
- fradiae
-
mycaminose
- enoyl-coa
- 3-hydroxyhexanoate
- isobutyryl-coa
Reaction
Synonyms
3-hydroxyacyl CoA reductase, acyl-CoA:NADP+ trans-2-oxidoreductase, bcd2, butanoyl-CoA:(acceptor) 2,3-oxidoreductase, butyryl coenzyme A dehydrogenase, butyryl dehydrogenase, butyryl-CoA dehydrogenase, butyryl-CoA dehydrogenase complex, CCR, CD1054, crotonyl CoA reductase, crotonyl coenzyme A reductase, crotonyl-CoA reductase, crotonyl-coenzyme A reductase, EgTER1, enoyl-coenzyme A reductase, ethylene reductase, short-chain acyl CoA dehydrogenase, short-chain acyl-coenzyme A dehydrogenase, trans-crotonyl CoA reductase, unsaturated acyl coenzyme A reductase, unsaturated acyl-CoA reductase
ECTree
1.3.1.86 crotonyl-CoA reductaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 1.3.1.86 - crotonyl-CoA reductase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(E)-but-2-enoyl-CoA + NADPH + H+
butanoyl-CoA + NADP+
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?
crotonyl-CoA + NADPH + H+
butanoyl-CoA + NADP+
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the enzyme exhibits a high substrate specificity for crotonyl-CoA
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-
?
trans-crotonyl-CoA + NADPH + H+
butyryl-CoA + NADP+
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the crotonyl-CoA reductase reaction requires NADPH as electron donor
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-
?
crotonyl-CoA + NADPH + H+
butyryl-CoA + NADP+
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the overall reduction of crotonyl-CoA proceeds in an anti fashion, the reaction proceeds with transfer of the hydrogen from the pro-4S position of NADPH to the Re face of the beta-carbon of crotonyl-CoA
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-
?
crotonyl-CoA + NADPH + H+
butyryl-CoA + NADP+
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-
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?
additional information
?
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the crotonyl-CoA reductase reaction requires NADPH as electron donor, but at a 20fold higher concentration NADH will substitute for NADPH with 50% Vmax
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?
additional information
?
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the enzyme is unable to catalyze the reduction of any other enoyl-CoA thioesters (acryloyl-CoA, trans-2-pentenoyl-CoA, trans-hexenoyl-CoA, trans-2-octenoyl-CoA, trans-2-dodecenoyl-CoA, trans-2-hexadecenoyl-CoA) or to utilize NADH as an electron donor. The enzyme is unable to reduce either the N-acetylcysteamine or the pantetheine thioester of crotonic acid
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?
