1.3.1.82: (-)-isopiperitenone reductase

This is an abbreviated version!
For detailed information about (-)-isopiperitenone reductase, go to the full flat file.

Word Map on EC 1.3.1.82

Reaction

(+)-cis-isopulegone
+
NADP+
=
(-)-isopiperitenone
+
NADPH
+
H+

Synonyms

More, isopiperitenone reductase, IPR, NADPH-dependent isopiperitenone reductase

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.82 (-)-isopiperitenone reductase

General Information

General Information on EC 1.3.1.82 - (-)-isopiperitenone reductase

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
metabolism
evolution
the enzyme belongs to the short-chain dehydrogenases/reductases SDR superfamily. A sequence alignment of the three ketoreductases MMR, MNMR, and salutaridine reductase (45-49% homology to Mentha enzymes) from Papaver somniferum with Mentha pipertita enzyme IPR shows each enzyme contains typical SDR-like motifs, such as those involved in central beta-sheet stabilization, and a TGxxxGhG motif
additional information
the catalytic acid residue in enzyme IPR is Glu238, analysis of its role in reaction mechanism