1.3.1.8: acyl-CoA dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about acyl-CoA dehydrogenase (NADP+), go to the full flat file.

Word Map on EC 1.3.1.8

Reaction

acyl-CoA
+
NADP+
=
2,3-dehydroacyl-CoA
+
NADPH
+
H+

Synonyms

2-enoyl-CoA reductase, 2-trans enoyl-CoA reductase, 2-trans-enoyl-CoA reductase, acyl coenzyme A dehydrogenase (nicotinamide adenine dinucleotide phosphate), CCR, crotonyl CoA reductase, crotonyl coenzyme A reductase, crotonyl-CoA reductase, crotonyl-coenzyme A reductase, dehydrogenase, acyl coenzyme A (nicotinamide adenine dinucleotide phosphate), enoyl coenzyme A reductase, enoyl-CoA reductase, MCAD, medium-chain acyl-CoA dehydrogenase, NADPH:enoyl-CoA oxidoreductase, NbECR, RCCR, trans-2-enoyl-CoA reductase

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.8 acyl-CoA dehydrogenase (NADP+)

Reference

Reference on EC 1.3.1.8 - acyl-CoA dehydrogenase (NADP+)

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Bernert, J.T.; Sprecher, H.
An analysis of partial reactions in the overall chain elongation of saturated and unsaturated fatty acids by rat liver microsomes
J. Biol. Chem.
252
6736-6744
1977
Rattus norvegicus
Manually annotated by BRENDA team
Bernert, J.T.; Sprecher, H.
The isolation of acyl-CoA derivatives as products of partial reactions in the microsomal chain elongation of fatty acids
Biochim. Biophys. Acta
573
436-442
1979
Rattus norvegicus
Manually annotated by BRENDA team
Prasad, M.R.; Chiang, C.F.; Cook, L.; Cinti, D.L.
Solubilization and purification of hepatic microsomal trans-2-enoyl-CoA reductase: evidence for the existence of a second long-chain enoyl-CoA reductase
Arch. Biochem. Biophys.
237
535-544
1985
Rattus norvegicus
Manually annotated by BRENDA team
Nagi, M.N.; Prasad, M.R.; Cook, L.; Cinti, D.
Biochemical properties of short- and long-chain rat liver microsomal trans-2-enoyl coenzyme A reductase
Arch. Biochem. Biophys.
226
50-64
1983
Rattus norvegicus
Manually annotated by BRENDA team
Prasad, M.R.; Nagi, M.N.; Cook, L.; Cinti, D.L.
Kinetic evidence for two separate trans-2-enoyl CoA reductases in rat hepatic microsomes: NADPH-specific short chain- and NAD(P)H-dependent long chain-reductase
Biochem. Biophys. Res. Commun.
113
659-665
1983
Rattus norvegicus
Manually annotated by BRENDA team
Cinti, D.L.; Nagi, M.N.; Cook, L.; White, R.E.
Evidence for a second microsomal trans-2-enoyl coenzyme A reductase in rat liver. NADPH-specific short chain reductase
J. Biol. Chem.
257
14333-14340
1982
Rattus norvegicus
Manually annotated by BRENDA team
Nagi, M.N.; Cook, L.; Ghesquier, D.; Cinti, D.L.
Site of inhibition of rat liver microsomal fatty acid chain elongation system by dec-2-ynoyl coenzyme A. Possible mechanism of inhibition
J. Biol. Chem.
261
13598-13605
1986
Rattus norvegicus
Manually annotated by BRENDA team
Nagi, M.N.; Cook, L.; Laguna, J.C.; Cinti, D.L.
Dual action of 2-decynoyl coenzyme A: inhibitor of hepatic mitochondrial trans-2-enoyl coenzyme A reductase and peroxisomal bifunctional protein and substrate for the mitochondrial beta-oxidation system
Arch. Biochem. Biophys.
267
1-12
1988
Rattus norvegicus
Manually annotated by BRENDA team
Laguna, J.C.; Nagi, M.; Cook, L.; Cinti, D.L.
Action of Ebselen on rat hepatic microsomal enzyme-catalyzed fatty acid chain elongation, desaturation, and drug biotransformation
Arch. Biochem. Biophys.
269
272-283
1989
Rattus norvegicus
Manually annotated by BRENDA team
Inui, H.; Miyatake, K.; Nakano, Y.; Kitaoka, S.
Fatty acid synthesis in mitochondria of Euglena gracilis
Eur. J. Biochem.
142
121-126
1984
Euglena gracilis
Manually annotated by BRENDA team
Kikuchi, S.; Kusaka, T.
Purification of NADPH-dependent enoyl-CoA reductase involved in the malonyl-CoA dependent fatty acid elongation system of Mycobacterium smegmatis
J. Biochem.
96
841-848
1984
Mycolicibacterium smegmatis
Manually annotated by BRENDA team
Strom, K.A.; Kumar, S.
Activation and inhibition of crotonyl-coenzyme A reductase activity of bovine mammary fatty acid synthetase
J. Biol. Chem.
254
8159-8162
1979
Bos taurus
-
Manually annotated by BRENDA team
Strom, K.A.; Galeos, W.L.; Davidson, L.A.; Kumar, S.
Enoyl coenzyme A reduction by bovine mammary fatty acid synthetase. Specificity and other characteristics
J. Biol. Chem.
254
8153-8158
1979
Bos taurus
Manually annotated by BRENDA team
Maitra, S.K.; Kumar, S.
Crotonyl coenzyme A reductase activity of bovine mammary fatty acid synthetase
J. Biol. Chem.
249
111-117
1974
Bos taurus
Manually annotated by BRENDA team
Ishidate, K.; Mizugaki, M.; Uchiyama, M.
Induction of NADPH enoyl-coA reductase in Candida grown in the presence of unsaturated fatty acids
J. Biochem.
76
1139-1142
1974
Candida albicans
Manually annotated by BRENDA team
Ishidate, K.; Mizugaki, M.; Uchiyama, M.
Separation and some characterizations of NADPH-enoyl CoA reductase(s) from Candida albicans
Chem. Pharm. Bull.
22
2685-2691
1974
Candida albicans
Manually annotated by BRENDA team
Mizugaki, M.; Uchiyama, M.
Stereospecific hydrogen transfer by NADPH-enoyl coenzyme A reductase to cis- and trans-isomers of 2-enoic acid
J. Biochem.
74
691-696
1973
Rattus norvegicus
Manually annotated by BRENDA team
Mizugaki, M.; Uchiyama, M.
Possible role of NADPH-dependent enoyl coenzyme A reductase in -oxidation of unsaturated fatty acids
Biochem. Biophys. Res. Commun.
50
48-53
1973
Rattus norvegicus
Manually annotated by BRENDA team
Podack, E.R.; Seubert, W.
On the mechanism of malonyl-CoA independent fatty acid synthesis. II. Isolation, properties and subcellular location of trans-2,3-hexenoyl-CoA and trans-2,3-decenoyl-CoA reductase
Biochim. Biophys. Acta
280
235-247
1972
Rattus norvegicus
Manually annotated by BRENDA team
Seubert, W.; Lamberts, I.; Kramer, R.; Ohly, B.
On the mechanism of malonyl-CoA-independent fatty acid synthesis. I. The mechanism of elongation of long-chain fatty acids by acetyl-CoA
Biochim. Biophys. Acta
164
498-517
1968
Rattus norvegicus
Manually annotated by BRENDA team
Mukherjee, S.; Katiyar, S.S.
Evidence for the essential histidine at the NADPH binding site of enoyl-CoA reductase domain of pigeon liver fatty acid synthetase
J. Enzyme Inhib.
11
209-216
1997
Columba sp.
Manually annotated by BRENDA team
Mukherjee, S.; Katiyar, S.S.
Inactivation of enoyl-CoA reductase in pigeon liver fatty acid synthetase by pyridoxal 5'-phosphate. Evidence for the presence of one lysine residue at the active site
J. Enzyme Inhib.
13
217-228
1998
Columba sp.
Manually annotated by BRENDA team
Cvetanovic, M.; Moreno de la Garza, M.; Dommes, V.; Kunau, W.H.
Purification and characterization of 2-enoyl-CoA-reductase from bovine liver
Biochem. J.
227
49-56
1985
Bos taurus
Manually annotated by BRENDA team
Sargueil, F.; Knoll, A.; Salles, J.; Garbay, B.; Cassagne, C.
High metabolism and subsequent elongation of 3-hydroxyeicosanoyl-CoA in very-long- chain fatty acid deficient PNS of Trembler mice
Neurosci. Lett.
273
29-32
1999
Mus musculus
Manually annotated by BRENDA team
Lessire, R.; Chevalier, S.; Lucet-Levannier, K.; Lellouche, J.P.; Mioskowski, C.; Cassagne, C.
Study of the 3-hydroxy-eicosanoyl-coenzyme A dehydratase and (E)-2,3 enoyl-coenzyme A reductase involved in acyl-coenzyme A elongation in etiolated leek seedlings
Plant Physiol.
119
1009-1015
1999
Allium ampeloprasum
Manually annotated by BRENDA team
Li, C.; Florova, G.; Akopiants, K.; Reynolds, K.A.
Crotonyl-coenzyme A reductase provides methylmalonyl-CoA precursors for monensin biosynthesis by Streptomyces cinnamonensis in an oil-based extended fermentation
Microbiology
150
3463-3472
2004
Streptomyces collinus
Manually annotated by BRENDA team
Park, J.; Kim, T.; Kim, S.; Kim, W.T.; Pai, H.
Silencing of NbECR encoding a putative enoyl-CoA reductase results in disorganized membrane structures and epidermal cell ablation in Nicotiana benthamiana
FEBS Lett.
579
4459-4464
2005
Nicotiana benthamiana, Nicotiana benthamiana (Q3IAA0)
Manually annotated by BRENDA team
Rennison, J.H.; McElfresh, T.A.; Okere, I.C.; Patel, H.V.; Foster, A.B.; Patel, K.K.; Stoll, M.S.; Minkler, P.E.; Fujioka, H.; Hoit, B.D.; Young, M.E.; Hoppel, C.L.; Chandler, M.P.
Enhanced acyl-CoA dehydrogenase activity is associated with improved mitochondrial and contractile function in heart failure
Cardiovasc. Res.
79
331-340
2008
Rattus norvegicus
Manually annotated by BRENDA team
Erb, T.J.; Berg, I.A.; Brecht, V.; Mueller, M.; Fuchs, G.; Alber, B.E.
Synthesis of C5-dicarboxylic acids from C2-units involving crotonyl-CoA carboxylase/reductase: the ethylmalonyl-CoA pathway
Proc. Natl. Acad. Sci. USA
104
10631-10636
2007
Rhodobacter sphaeroides
Manually annotated by BRENDA team
Sugishima, M.; Okamoto, Y.; Noguchi, M.; Kohchi, T.; Tamiaki, H.; Fukuyama, K.
Crystal structures of the substrate-bound forms of red chlorophyll catabolite reductase: implications for site-specific and stereospecific reaction
J. Mol. Biol.
402
879-891
2010
Arabidopsis thaliana
Manually annotated by BRENDA team