1.3.1.8: acyl-CoA dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about acyl-CoA dehydrogenase (NADP+), go to the full flat file.

Word Map on EC 1.3.1.8

Reaction

acyl-CoA
+
NADP+
=
2,3-dehydroacyl-CoA
+
NADPH
+
H+

Synonyms

2-enoyl-CoA reductase, 2-trans enoyl-CoA reductase, 2-trans-enoyl-CoA reductase, acyl coenzyme A dehydrogenase (nicotinamide adenine dinucleotide phosphate), CCR, crotonyl CoA reductase, crotonyl coenzyme A reductase, crotonyl-CoA reductase, crotonyl-coenzyme A reductase, dehydrogenase, acyl coenzyme A (nicotinamide adenine dinucleotide phosphate), enoyl coenzyme A reductase, enoyl-CoA reductase, MCAD, medium-chain acyl-CoA dehydrogenase, NADPH:enoyl-CoA oxidoreductase, NbECR, RCCR, trans-2-enoyl-CoA reductase

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.8 acyl-CoA dehydrogenase (NADP+)

Inhibitors

Inhibitors on EC 1.3.1.8 - acyl-CoA dehydrogenase (NADP+)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-decynoyl-CoA
-
-
2-methylcrotonyl-CoA
-
CoA-activated enzyme, competitive inhibition
2-trans-octadecenoyl-CoA
-
without bovine serum albumin substrate-induced inhibition at 0.02-0.03 mM
3-methylcrotonyl-CoA
-
-
4-Chloro-7-nitrobenzo-2-oxa-1,3-diazole
-
-
5,5'-dithiobis(2-nitrobenzoate)
-
-
acetyl-CoA
-
competitive
butyryl-CoA
coenzyme A
-
in free form inhibits fatty acid sythesis
diethyldicarbonate
-
-
dithiothreitol
-
above 10 mM
ebselen
-
i.e. 2-phenylisoselenazol-3-one
iodoacetamide
-
-
Isonicotinamide
-
-
malonyl-CoA
-
non-competitive
methylmalonyl-CoA
-
i.e. tiglyl-CoA
monoiodoacetate
-
-
N-ethylmaleimide
NADH
-
in presence of NADPH 0.1 mM
NADPH
-
concentration above 0.1 mM
p-chloromercuribenzoate
palmitoyl-CoA
-
without bovine serum albumin substrate-induced inhibition at 0.02-0.03 mM
pyridoxal 5'-phosphate
-
competitive with NADPH, 80% inactivation at 1 mM, reversibel
trans-2-hexenoyl-CoA
-
competitive inhibition of crotonoyl-CoA reduction, but not of 2-trans-hexadecenoyl-CoA and 2-trans-decenoyl-CoA reduction