1.3.1.78: arogenate dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about arogenate dehydrogenase (NADP+), go to the full flat file.

Reaction

Synonyms

ADH1, ADH2, arogenate dehydrogenase, arogenate dehydrogenase isoform 1, arogenate dehydrogenase isoform 2, cyclohexadienyl dehydrogenase, TyrA arogenate dehydrogenase, TyrA1, TyrA2, TyrAa, TyrAAT, TyrAAT1, TyrAsy

ECTree

     1 Oxidoreductases

         1.3 Acting on the CH-CH group of donors

             1.3.1 With NAD⁺ or NADP⁺ as acceptor

                1.3.1.78 arogenate dehydrogenase (NADP+)

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Results	in table
63	AA Sequence
1	CAS Registry Number
6	Cloned(Commentary)
45	Cofactor
1	Crystallization (Commentary)
5	General Information
1	General Stability
39	Inhibitors
25	Ki Value [mM]
34	KM Value [mM]
3	Localization
10	Molecular Weight [Da]
37	Natural Substrates/ Products (Substrates)
48	Organism
4	Pathway
5	pH Optimum
1	pH Range
1	Protein Variants
11	Purification (Commentary)
2	Reaction
3	Reaction Type
39	Reference
4	Source Tissue
20	Specific Activity [micromol/min/mg]
1	Storage Stability
88	Substrates and Products (Substrate)
4	Subunits
25	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
1	Temperature Range [°C]
3	Turnover Number [1/s]

General Information

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General Information on EC 1.3.1.78 - arogenate dehydrogenase (NADP+)

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

evolution

Arabidopsis thaliana

Q944B6, Q9LMR3

prephenate dehydrogenases (TyrAps, also known as PDHs) from two legumes, Glycine max (soybean) and Medicago truncatula, are phylogenetically distinct from canonical plant ADH enzymes, prefer prephenate to arogenate substrate, localize outside of the plastids and are not inhibited by L-Tyr. Diversification of primary metabolic Tyr pathway via an alternative cytosolic PDH pathway in plants, phylogenetic and biochemical differentiation of ADHs and PDHs

745837

malfunction

2 entries

metabolism

2 entries

malfunction

Arabidopsis thaliana

Q944B6, Q9LMR3

TyrA1 suppression reduces seed yield due to impaired anther dehiscence

763581

malfunction

Arabidopsis thaliana

Q944B6, Q9LMR3

TyrA2 knockout leads to slow growth with reticulate leaves. TyrA2 deficiency alters the levels of multiple amino acids but not of tyrosine

763581

metabolism

Arabidopsis thaliana

Q944B6, Q9LMR3

in plants, L-Tyr is synthe­sized in the plastids via the arogenate dehydrogenase pathway, in which prephenate is first converted to arogenate by prephenate aminotransferase, EC 2.6.1.7, and then to L-Tyr by enzyme ADH

745837

metabolism

Arabidopsis thaliana

Q944B6, Q9LMR3

most plants synthesize tyrosine by TyrA arogenate dehydrogenases. TyrA1 and TyrA2 have distinct and overlapping functions in flower and leaf development, respectively. The imbalance of tyrosine, caused by altered TyrA activity and regulation, impacts growth and development of Arabidopsis

763581