1.3.1.74: 2-alkenal reductase [NAD(P)+]

This is an abbreviated version!
For detailed information about 2-alkenal reductase [NAD(P)+], go to the full flat file.

Word Map on EC 1.3.1.74

Reaction

a n-alkanal
+
NAD(P)+
=
an alk-2-enal
+
NAD(P)H
+
H+

Synonyms

2-alkenal reductase, 2AER, AER, alkenal/one oxidoreductase, alkenal/one reductase, AOR, At-AER, At5g16970, AtAOR, bifunctional LTB4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase, CS-670 double-bond reductase, CsAOR, Dbr1, double bond reductase, LTB4 12-HD/PGR, NADPH alkenal/one oxidoreductase, NADPH-dependent alkenal/one oxidoreductase

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.74 2-alkenal reductase [NAD(P)+]

Reference

Reference on EC 1.3.1.74 - 2-alkenal reductase [NAD(P)+]

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Stoffel, W.; Därr, W.
Purification and characterization of 2-alkenal reductase
Hoppe-Seyler's Z. Physiol. Chem.
356
385-390
1975
Rattus norvegicus
Manually annotated by BRENDA team
Dick, R.A.; Kwak, M.K.; Sutter, T.R.; Kensler, T.W.
Antioxidative function and substrate specificity of NAD(P)H-dependent alkenal/one oxidoreductase. A new role for leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase
J. Biol. Chem.
276
40803-40810
2001
Rattus norvegicus
Manually annotated by BRENDA team
Mano, J.i.; Torii, Y.; Hayashi, S.i.; Takimoto, K.; Matsui, K.; Nakamura, K.; Inze, D.; Babiychuk, E.; Kushnir, S.; Asada, K.
The NADPH:quinone oxidoreductase P1-x-crystallin in Arabidopsis catalyzes the alpha,beta-hydrogenation of 2-alkenals: Detoxication of the lipid peroxide-derived reactive aldehydes
Plant Cell Physiol.
43
1445-1455
2002
Arabidopsis thaliana
Manually annotated by BRENDA team
Dick, R.A.; Yu, X.; Kensler, T.W.
NADPH alkenal/one oxidoreductase activity determines sensitivity of cancer cells to the chemotherapeutic alkylating agent irofulven
Clin. Cancer Res.
10
1492-1499
2004
Rattus norvegicus
Manually annotated by BRENDA team
Dick, R.A.; Kensler, T.W.
The catalytic and kinetic mechanisms of NADPH-dependent alkenal/one oxidoreductase
J. Biol. Chem.
279
17269-17277
2004
Rattus norvegicus
Manually annotated by BRENDA team
Yu, X.; Egner, P.A.; Wakabayashi, J.; Wakabayashi, N.; Yamamoto, M.; Kensler, T.W.
Nrf2-mediated induction of cytoprotective enzymes by 15-deoxy-DELTA12,14-prostaglandin J2 is attenuated by alkenal/one oxidoreductase
J. Biol. Chem.
281
26245-26252
2006
Rattus norvegicus
Manually annotated by BRENDA team
Gong, J.; Neels, J.F.; Yu, X.; Kensler, T.W.; Peterson, L.A.; Sturla, S.J.
Investigating the role of stereochemistry in the activity of anticancer acylfulvenes: synthesis, reductase-mediated bioactivation, and cellular toxicity
J. Med. Chem.
49
2593-2599
2006
Homo sapiens
Manually annotated by BRENDA team
Mano, J.; Belles-Boix, E.; Babiychuk, E.; Inze, D.; Torii, Y.; Hiraoka, E.; Takimoto, K.; Slooten, L.; Asada, K.; Kushnir, S.
Protection against photooxidative injury of tobacco leaves by 2-alkenal reductase. Detoxication of lipid peroxide-derived reactive carbonyls
Plant Physiol.
139
1773-1783
2005
Arabidopsis thaliana
Manually annotated by BRENDA team
Papdi, C.; Abraham, E.; Joseph, M.P.; Popescu, C.; Koncz, C.; Szabados, L.
Functional identification of Arabidopsis stress regulatory genes using the controlled cDNA overexpression system
Plant Physiol.
147
528-542
2008
Arabidopsis thaliana
Manually annotated by BRENDA team
Itoh, K.; Yamamoto, K.; Adachi, M.; Kosaka, T.; Tanaka, Y.
Leukotriene B4 12-hydroxydehydrogenase/15-ketoprostaglandin DELTA13-reductase (LTB4 12-HD/PGR) responsible for the reduction of a double-bond of the alpha,beta-unsaturated ketone of an aryl propionic acid non-steroidal anti-inflammatory agent CS-670
Xenobiotica
38
249-263
2008
Rattus norvegicus
Manually annotated by BRENDA team
Zhang, Y.; Teoh, K.; Reed, D.; Covello, P.
Molecular cloning and characterization of Dbr1, a 2-alkenal reductase from Artemisia annua
Botany
87
643-649
2009
Artemisia annua
-
Manually annotated by BRENDA team
Yamauchi, Y.; Hasegawa, A.; Taninaka, A.; Mizutani, M.; Sugimoto, Y.
NADPH-dependent reductases involved in the detoxification of reactive carbonyls in plants
J. Biol. Chem.
286
6999-7009
2011
Arabidopsis thaliana, Cucumis sativus, Cucumis sativus (E2S0A5), Cucumis sativus (E2S0A6)
Manually annotated by BRENDA team
Mano, J.; Tokushige, K.; Mizoguchi, H.; Fujii, H.; Khorobrykh, S.
Accumulation of lipid peroxide-derived, toxic alpha, beta-unsaturated aldehydes (E)-2-pentenal, acrolein and (E)-2-hexenal in leaves under photoinhibitory illumination
Plant Biotechnol.
27
193-197
2010
Arabidopsis thaliana
-
Manually annotated by BRENDA team