1.3.1.72: DELTA24-sterol reductase This is an abbreviated version! For detailed information about DELTA24-sterol reductase, go to the full flat file .
Reaction
5alpha-Cholest-7-en-3beta-ol +
NADP+ =
5alpha-cholesta-7,24-dien-3beta-ol +
NADPH +
H+
Synonyms 24,25-reductase, 24,25-sterol reductase, 24-dehydrocholesterol reductase, 24-reductase, 3 beta-hydroxysteroid-DELTA 24 reductase, 3-beta-hydroxysterol-DELTA24-reductase, 3beta -hydroxysterol DELTA24-reductase, 3beta-hydroxysteroid-DELTA24 reductase, 3beta-hydroxysterol DELTA24-reductase, 3beta-hydroxysterol-delta24 reductase, ArDWF1, C-24 reductase, dehydrocholesterol reductase, DELTA24 reductase, DELTA24-dehydrocholesterol reductase, DELTA24-reductase, DELTA24-sterol-DELTA24-reductase, desmosterol reductase, DHCR24, DHCR24-1, DHCR24-2, DIM, DIMINUTO/DWARF1, Dimunito/Dwarf1, DWARF1, DWF1, hydroxy steroid DELTA24-reductase, lanosterol 24-reductase, lanosterol DELTA24-reductase, lanosterol reductase, More, OsDWF1, reductase, hydroxy steroid DELTA24-, seladin-1, sterol 24,25-reductase, sterol 24-reductase, sterol 24DELTA-reductase, sterol C-24 reductase, sterol DELTA24 reductase, sterol DELTA24-reductase, sterol-DELTA24-reductase, ZmDWF1
ECTree
Source Tissue
Source Tissue on EC 1.3.1.72 - DELTA24-sterol reductase
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intestinal mucosa cells
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abundantly expressed throughout the epidermis except for the stratum corneum and in hair follicles
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fibroblast from skin
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highest expression in gonad of females
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DHCR24 is specifically expressed on the surface of HCC cell lines
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BE(2)C cell line
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a human hepatoblastoma-derived cell line
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human skin fibroblast
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hepatoma cell line HepG2
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promyelocytic cells
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highest expression in liver of females
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predominant enzymatic activity in the larval midgut
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additional information
DHCR24 is expressed in all cells/tissues that synthesize cholesterol, with the highest expression in cholesterogenic (brain and liver) and steroidogenic tissues (endocrine glands like adrenal, testes, and ovaries)
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additional information
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DHCR24 is expressed in all cells/tissues that synthesize cholesterol, with the highest expression in cholesterogenic (brain and liver) and steroidogenic tissues (endocrine glands like adrenal, testes, and ovaries)
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additional information
not in glial cells
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additional information
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no activity in J774 cells, that lack a full-length transcript for DHCR24
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additional information
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no activity in J774 cells, that lack a full-length transcript for DHCR24. J774 cells are able to grow indefinitely after the virtually total replacement of cholesterol by desmosterol, i.e. J774-D cells
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