1.3.1.72: DELTA24-sterol reductase This is an abbreviated version! For detailed information about DELTA24-sterol reductase, go to the full flat file .
Reaction
5alpha-Cholest-7-en-3beta-ol +
NADP+ =
5alpha-cholesta-7,24-dien-3beta-ol +
NADPH +
H+
Synonyms 24,25-reductase, 24,25-sterol reductase, 24-dehydrocholesterol reductase, 24-reductase, 3 beta-hydroxysteroid-DELTA 24 reductase, 3-beta-hydroxysterol-DELTA24-reductase, 3beta -hydroxysterol DELTA24-reductase, 3beta-hydroxysteroid-DELTA24 reductase, 3beta-hydroxysterol DELTA24-reductase, 3beta-hydroxysterol-delta24 reductase, ArDWF1, C-24 reductase, dehydrocholesterol reductase, DELTA24 reductase, DELTA24-dehydrocholesterol reductase, DELTA24-reductase, DELTA24-sterol-DELTA24-reductase, desmosterol reductase, DHCR24, DHCR24-1, DHCR24-2, DIM, DIMINUTO/DWARF1, Dimunito/Dwarf1, DWARF1, DWF1, hydroxy steroid DELTA24-reductase, lanosterol 24-reductase, lanosterol DELTA24-reductase, lanosterol reductase, More, OsDWF1, reductase, hydroxy steroid DELTA24-, seladin-1, sterol 24,25-reductase, sterol 24-reductase, sterol 24DELTA-reductase, sterol C-24 reductase, sterol DELTA24 reductase, sterol DELTA24-reductase, sterol-DELTA24-reductase, ZmDWF1
ECTree
Localization
Localization on EC 1.3.1.72 - DELTA24-sterol reductase
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hepatocellular carcinoma cells, hepatoblastoma cell line, and cervical adenocarcinoma-derived cell line
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a predicted transmembrane (TM) domain-deleted DHCR24 mutation is localized to the cytoplasm
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DHCR24 membrane association
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DHCR24 associates strongly with the endoplasmic reticulum beyond predicted membrane domains. The majority of the enzyme is associated with the endoplasmic reticulum membrane. The predicted membrane topology of DHCR24 consists of N-terminal transmembrane domains. The putative transmembrane domain is not essential for DHCR24 membrane association
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primarily, a putative transmembrane domain exists in the N-terminus of DHCR24
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bound
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DHCR24 possesses a putative transmembrane segment
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DHCR24 membrane association
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bound
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membrane-bound
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microsome-bound
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microsome-bound
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additional information
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enzyme DWF1 has a strong membrane association and a cytoplasmic C-terminus
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enzyme DHCR24 is not predicted to associate with the membrane via post-translational modifications. The enzyme sequence contains a secretory signal peptide and an extremely hydrophobic N-terminus, hydrophobicity profile overview
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no DHCR24 expression on the surface of the normal human hepatocyte lines NKNT and TTNT
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smaller variants of DHCR24 (about 40 kDa) produced by caspase cleavage during apoptosis are cytoplasmic
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additional information
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smaller variants of DHCR24 (about 40 kDa) produced by caspase cleavage during apoptosis are cytoplasmic
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