1.3.1.54: precorrin-6A reductase
This is an abbreviated version!
For detailed information about precorrin-6A reductase, go to the full flat file.
Reaction
Synonyms
precorrin 6-X reductase, precorrin-6 reductase, precorrin-6A reductase, precorrin-6x reductase, precorrin-6Y:NADP+ oxidoreductase, Reductase, precorrin 6x (Pseudomonas denitrificans clone pXL367 gene cobK)
ECTree
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Substrates Products on EC 1.3.1.54 - precorrin-6A reductase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
precorrin-6A + NADPH
precorrin-6B + NADP+
-
enzyme catalyzes step 10 in the biosynthesis of cobalamine, vitamin B12, pathway overview
-
-
?
precorrin-6A + NADPH
precorrin-6B + NADP+
-
step in the biosynthesis of cobalamine, vitamin B12
-
-
?
precorrin-6A + NADPH
precorrin-6B + NADP+
-
stereospecific hydride transfer from NADPH to the enzyme, NMR analysis of reaction product, deuterium-labeling
-
-
?
precorrin-6A + NADPH
precorrin-6B + NADP+
Pseudomonas denitrificans (nom. rej.) SC510 Rif
-
step in the biosynthesis of cobalamine, vitamin B12
-
-
?
precorrin-6A + NADPH
precorrin-6B + NADP+
Pseudomonas denitrificans (nom. rej.) SC510 Rif
-
stereospecific hydride transfer from NADPH to the enzyme, NMR analysis of reaction product, deuterium-labeling
-
-
?
Precorrin-6X + NADPH
Precorrin-6Y + NADP+
-
reduction step along the pathway to corrins
-
-
?
additional information
?
-
enzyme is essential for biosynthesis of cobalamin, i.e. vitamin B12, anaerobic growth of the pleiotrophic mutant is affected when either nitrate, nitrite, or nitrous oxide is used as terminal electron acceptor, which is reversible by addition of cobalamine or cobinamide to the minimal medium
-
-
?
additional information
?
-
-
enzyme is essential for biosynthesis of cobalamin, i.e. vitamin B12, anaerobic growth of the pleiotrophic mutant is affected when either nitrate, nitrite, or nitrous oxide is used as terminal electron acceptor, which is reversible by addition of cobalamine or cobinamide to the minimal medium
-
-
?
additional information
?
-
enzyme is essential for biosynthesis of cobalamin, i.e. vitamin B12, anaerobic growth of the pleiotrophic mutant is affected when either nitrate, nitrite, or nitrous oxide is used as terminal electron acceptor, which is reversible by addition of cobalamine or cobinamide to the minimal medium
-
-
?
