1.3.1.48: 13,14-dehydro-15-oxoprostaglandin 13-reductase

This is an abbreviated version!
For detailed information about 13,14-dehydro-15-oxoprostaglandin 13-reductase, go to the full flat file.

Word Map on EC 1.3.1.48

Reaction

11alpha-hydroxy-9,15-dioxoprostanoate
+
NAD(P)+
=
(13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate
+
NAD(P)H
+
H+

Synonyms

15-hydroxyprostaglandin dehydrogenase, 15-keto-PG reductase, 15-ketoprostaglandin DELTA-13-reductase, 15-ketoprostaglandin DELTA13-reductase, 15-ketoprostaglandinDELTA13-reductase, 15-oxoprostaglandin 13-oxidase, 15-oxoprostaglandin 13-reductase, 15-oxoprostaglandin DELTA13-reductase, 15-oxoprostaglandin-DELTA13-reductase, 15-PGDH, Ad-PGR, bifunctional leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase, bifunctional LTB4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase, DELTA13-15-ketoprostaglandin reductase, leukotriene B4 12-hydroxydehydrogenase/15-ketoprostaglandin 13-reductase, leukotriene B4 dehydrogenase, leukotriene B4-12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase, LTB4 12-HD/PGR, LTBDH/PGR, NAD(P)H-dependent alkenal/one oxidoreductase, PG reductase, PGR, PGR-2, PGR1, prostaglandin 13-reductase, prostaglandin DELTA13-reductase, prostaglandin reductase 1, reductase, 15-oxo-DELTA13-prostaglandin

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.48 13,14-dehydro-15-oxoprostaglandin 13-reductase

Turnover Number

Turnover Number on EC 1.3.1.48 - 13,14-dehydro-15-oxoprostaglandin 13-reductase

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.7 - 1
15-ketoprostaglandin E
-
-
0.12 - 1.52
15-ketoprostaglandin E1
0.19
15-ketoprostaglandin E2
in 0.1 M Tris-HCl (pH 7.4), at 37°C
0.22
15-ketoprostaglandin F1alpha
in 0.1 M Tris-HCl (pH 7.4), at 37°C
0.25
15-ketoprostaglandin F2alpha
in 0.1 M Tris-HCl (pH 7.4), at 37°C
40
15-oxoprostaglandin E1
-
-
19.8
3-nonen-2-one
-
-
18.5
3-penten-2-one
-
-
13.4
4-hydroxy-2-hexenal
-
-
67.3
4-hydroxy-2-nonenal
-
-
3.72
acrolein
-
-
13.1
alpha-methylcinnamaldehyde
-
-
54.7
benzylidene acetone
-
-
32.3
chalcone
-
-
15.7
cinnamaldehyde
-
-
8.05
crotonaldehyde
-
-
160
ethylvinylketone
-
-
156
methylvinylketone
-
-
0.16
NADPH
in 0.1 M Tris-HCl (pH 7.4), at 37°C
17.2
trans,trans-2,4-nonadienal
-
-
70.8
trans-2-decenal
-
-
60.2
trans-2-dodecenal
-
-
28.8
trans-2-hexenal
-
-
94.5
trans-2-nonenal
-
-
89.7
trans-2-octenal
-
-
16.8
trans-2-pentenal
-
-