1.3.1.48: 13,14-dehydro-15-oxoprostaglandin 13-reductase

This is an abbreviated version!
For detailed information about 13,14-dehydro-15-oxoprostaglandin 13-reductase, go to the full flat file.

Word Map on EC 1.3.1.48

Reaction

11alpha-hydroxy-9,15-dioxoprostanoate
+
NAD(P)+
=
(13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate
+
NAD(P)H
+
H+

Synonyms

15-hydroxyprostaglandin dehydrogenase, 15-keto-PG reductase, 15-ketoprostaglandin DELTA-13-reductase, 15-ketoprostaglandin DELTA13-reductase, 15-ketoprostaglandinDELTA13-reductase, 15-oxoprostaglandin 13-oxidase, 15-oxoprostaglandin 13-reductase, 15-oxoprostaglandin DELTA13-reductase, 15-oxoprostaglandin-DELTA13-reductase, 15-PGDH, Ad-PGR, bifunctional leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase, bifunctional LTB4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase, DELTA13-15-ketoprostaglandin reductase, leukotriene B4 12-hydroxydehydrogenase/15-ketoprostaglandin 13-reductase, leukotriene B4 dehydrogenase, leukotriene B4-12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase, LTB4 12-HD/PGR, LTBDH/PGR, NAD(P)H-dependent alkenal/one oxidoreductase, PG reductase, PGR, PGR-2, PGR1, prostaglandin 13-reductase, prostaglandin DELTA13-reductase, prostaglandin reductase 1, reductase, 15-oxo-DELTA13-prostaglandin

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.48 13,14-dehydro-15-oxoprostaglandin 13-reductase

Reference

Reference on EC 1.3.1.48 - 13,14-dehydro-15-oxoprostaglandin 13-reductase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hansen, H.S.
Purification and assay of 15-ketoprostaglandin delta 13-reductase from bovine lung
Methods Enzymol.
86
156-167
1982
Bos taurus, Gallus gallus, Homo sapiens
Manually annotated by BRENDA team
Jarabak, J.
Isolation and properties of a 15-ketoprostaglandin delta 13-reductase from human placenta
Methods Enzymol.
86
163-167
1982
Homo sapiens
Manually annotated by BRENDA team
Westbrook, C.; Jarabak, J.
Purification and partial characterization of an NADH-linked delta13-15-ketoprostaglandin reductase from human placenta
Biochem. Biophys. Res. Commun.
66
541-546
1975
Homo sapiens
Manually annotated by BRENDA team
Hansen, H.S.
Purification and characterization of a 15-ketoprostaglandin delta 13-reductase from bovine lung
Biochim. Biophys. Acta
574
136-145
1979
Bos taurus
Manually annotated by BRENDA team
Westbrook, C.; Jarabak, J.
15-Ketoprostaglandin delta13 reductase from human placenta: purification, kinetics, and inhibitor binding
Arch. Biochem. Biophys.
185
429-442
1978
Homo sapiens
Manually annotated by BRENDA team
Nikaido, H.; Moriishi, M.; Mishima, H.K.; Kitamura, S.; Tatsumi, K.
15-Ketoprostaglandin delta 13-reductase activity in bovine ocular tissues
Curr. Eye Res.
12
17-22
1993
Bos taurus
Manually annotated by BRENDA team
Kitamura, S.; Katsura, H.; Tatsumi, K.
Purification of a 15-ketoprostaglandin DELTA13-reductase from rat liver and its ability to reduce the double bond of xenobiotics
Biochem. Mol. Biol. Int.
30
839-847
1993
Rattus norvegicus
Manually annotated by BRENDA team
Ensor, C.M.; Zhang, H.; Tai, H.H.
Purification, cDNA cloning and expression of 15-oxoprostaglandin 13-reductase from pig lung
Biochem. J.
330
103-108
1998
Bos taurus, Sus scrofa
-
Manually annotated by BRENDA team
Clish, C.B.; Levy, B.D.; Chiang, N.; Tai, H.H.; Serhan, C.N.
Oxidoreductases in lipoxin A4 metabolic inactivation: a novel role for 15-oxoprostaglandin 13-reductase/leukotriene B4 12-hydroxydehydrogenase in inflammation
J. Biol. Chem.
275
25372-25380
2000
Sus scrofa
Manually annotated by BRENDA team
Yamamoto, T.; Yokomizo, T.; Nakao, A.; Izumi, T.; Shimizu, T.
Immunohistochemical localization of guinea-pig leukotriene B4 12-hydroxydehydrogenase/15-ketoprostaglandin 13-reductase
Eur. J. Biochem.
268
6105-6113
2001
Cavia porcellus
Manually annotated by BRENDA team
Dick, R.A.; Kwak, M.K.; Sutter, T.R.; Kensler, T.W.
Antioxidative function and substrate specificity of NAD(P)H-dependent alkenal/one oxidoreductase. A new role for leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase
J. Biol. Chem.
276
40803-40810
2001
Rattus norvegicus
Manually annotated by BRENDA team
Hori, T.; Yokomizo, T.; Ago, H.; Sugahara, M.; Ueno, G.; Yamamoto, M.; Kumasaka, T.; Shimizu, T.; Miyano, M.
Structural basis of leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase catalytic mechanism and a possible Src homology 3 domain binding loop
J. Biol. Chem.
279
22615-22623
2004
Cavia porcellus
Manually annotated by BRENDA team
Hori, T.; Ishijima, J.; Yokomizo, T.; Ago, H.; Shimizu, T.; Miyano, M.
Crystal structure of anti-configuration of indomethacin and leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase complex reveals the structural basis of broad spectrum indomethacin efficacy
J. Biochem.
140
457-466
2006
Cavia porcellus
Manually annotated by BRENDA team
Chou, W.L.; Chuang, L.M.; Chou, C.C.; Wang, A.H.; Lawson, J.A.; FitzGerald, G.A.; Chang, Z.F.
Identification of a novel prostaglandin reductase reveals the involvement of prostaglandin E2 catabolism in regulation of peroxisome proliferator-activated receptor gamma activation
J. Biol. Chem.
282
18162-18172
2007
Mus musculus (Q8VDQ1)
Manually annotated by BRENDA team
Itoh, K.; Yamamoto, K.; Adachi, M.; Kosaka, T.; Tanaka, Y.
Leukotriene B4 12-hydroxydehydrogenase/15-ketoprostaglandin DELTA13-reductase (LTB4 12-HD/PGR) responsible for the reduction of a double-bond of the alpha,beta-unsaturated ketone of an aryl propionic acid non-steroidal anti-inflammatory agent CS-670
Xenobiotica
38
249-263
2008
Rattus norvegicus
Manually annotated by BRENDA team
Zhao, Y.; Weng, C.C.; Tong, M.; Wei, J.; Tai, H.H.
Restoration of leukotriene B(4)-12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase (LTBDH/PGR) expression inhibits lung cancer growth in vitro and in vivo
Lung Cancer
68
161-169
2010
Sus scrofa (Q29073)
Manually annotated by BRENDA team
Mesa, J.; Alsina, C.; Oppermann, U.; Pares, X.; Farres, J.; Porte, S.
Human prostaglandin reductase 1 (PGR1) Substrate specificity, inhibitor analysis and site-directed mutagenesis
Chem. Biol. Interact.
234
105-113
2015
Homo sapiens, Homo sapiens (P15428)
Manually annotated by BRENDA team
Piao, Y.; Wu, Y.; Seo, S.; Lim, S.; Cho, H.
Wound healing effects of new 15-hydroxyprostaglandin dehydrogenase inhibitors
Prostaglandins Leukot. Essent. Fatty Acids
91
325-332
2014
Homo sapiens
Manually annotated by BRENDA team