1.3.1.48: 13,14-dehydro-15-oxoprostaglandin 13-reductase

This is an abbreviated version!
For detailed information about 13,14-dehydro-15-oxoprostaglandin 13-reductase, go to the full flat file.

Word Map on EC 1.3.1.48

Reaction

11alpha-hydroxy-9,15-dioxoprostanoate
+
NAD(P)+
=
(13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate
+
NAD(P)H
+
H+

Synonyms

15-hydroxyprostaglandin dehydrogenase, 15-keto-PG reductase, 15-ketoprostaglandin DELTA-13-reductase, 15-ketoprostaglandin DELTA13-reductase, 15-ketoprostaglandinDELTA13-reductase, 15-oxoprostaglandin 13-oxidase, 15-oxoprostaglandin 13-reductase, 15-oxoprostaglandin DELTA13-reductase, 15-oxoprostaglandin-DELTA13-reductase, 15-PGDH, Ad-PGR, bifunctional leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase, bifunctional LTB4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase, DELTA13-15-ketoprostaglandin reductase, leukotriene B4 12-hydroxydehydrogenase/15-ketoprostaglandin 13-reductase, leukotriene B4 dehydrogenase, leukotriene B4-12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase, LTB4 12-HD/PGR, LTBDH/PGR, NAD(P)H-dependent alkenal/one oxidoreductase, PG reductase, PGR, PGR-2, PGR1, prostaglandin 13-reductase, prostaglandin DELTA13-reductase, prostaglandin reductase 1, reductase, 15-oxo-DELTA13-prostaglandin

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.48 13,14-dehydro-15-oxoprostaglandin 13-reductase

KM Value

KM Value on EC 1.3.1.48 - 13,14-dehydro-15-oxoprostaglandin 13-reductase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.093
(5S,12R)-dihydroxy-(6E,8Z,10Z,14E)-eicosatetraenoic acid
-
-
0.0085
15-keto-prostaglandin E2
-
-
0.0075
15-ketoprostaglandin A1
-
-
0.0112
15-ketoprostaglandin B1
-
-
0.0039 - 0.0344
15-ketoprostaglandin E1
0.0078 - 0.07
15-ketoprostaglandin E2
0.0592 - 0.184
15-ketoprostaglandin F1alpha
0.000213 - 0.1088
15-ketoprostaglandin F2alpha
0.001
15-oxoprostaglandin E1
-
-
0.016
3-nonen-2-one
-
-
0.49
3-penten-2-one
-
-
0.21
4-hydroxy-2-hexenal
-
-
0.12 - 0.461
4-hydroxy-2-nonenal
0.258
6,15-diketo-prostaglandin F1alpha
-
-
0.15
acrolein
-
-
1.7
alpha-methylcinnamaldehyde
-
-
0.0277 - 0.039
benzylidene acetone
0.1399
benzylidene acetonphenone
-
in 100 mM phosphate buffer (pH 7.4), at 25C
0.18
chalcone
-
-
0.075 - 1.426
cinnamaldehyde
0.0791
cinnamoylthiophene
-
in 100 mM phosphate buffer (pH 7.4), at 25C
3.9
crotonaldehyde
-
-
0.11
ethylvinylketone
-
-
0.01
leukotriene B4
-
recombinant enzyme
0.1289
Methyl vinyl ketone
-
in 100 mM phosphate buffer (pH 7.4), at 25C
0.58
methylvinylketone
-
-
0.032 - 0.16
NADH
0.005 - 0.0946
NADPH
0.063
nicotinamide hypoxanthine dinucleotide
-
-
0.0123
phenyl propenyl ketone
-
in 100 mM phosphate buffer (pH 7.4), at 25C
0.41
trans,trans-2,4-nonadienal
-
-
0.04
trans-2-decenal
-
-
0.06
trans-2-dodecenal
-
-
1 - 2.194
trans-2-hexenal
0.046
trans-2-nonenal
-
-
0.36
trans-2-octenal
-
-
2.4
trans-2-pentenal
-
-