1.3.1.48: 13,14-dehydro-15-oxoprostaglandin 13-reductase

This is an abbreviated version!
For detailed information about 13,14-dehydro-15-oxoprostaglandin 13-reductase, go to the full flat file.

Word Map on EC 1.3.1.48

Reaction

11alpha-hydroxy-9,15-dioxoprostanoate
+
NAD(P)+
=
(13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate
+
NAD(P)H
+
H+

Synonyms

15-hydroxyprostaglandin dehydrogenase, 15-keto-PG reductase, 15-ketoprostaglandin DELTA-13-reductase, 15-ketoprostaglandin DELTA13-reductase, 15-ketoprostaglandinDELTA13-reductase, 15-oxoprostaglandin 13-oxidase, 15-oxoprostaglandin 13-reductase, 15-oxoprostaglandin DELTA13-reductase, 15-oxoprostaglandin-DELTA13-reductase, 15-PGDH, Ad-PGR, bifunctional leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase, bifunctional LTB4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase, DELTA13-15-ketoprostaglandin reductase, leukotriene B4 12-hydroxydehydrogenase/15-ketoprostaglandin 13-reductase, leukotriene B4 dehydrogenase, leukotriene B4-12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase, LTB4 12-HD/PGR, LTBDH/PGR, NAD(P)H-dependent alkenal/one oxidoreductase, PG reductase, PGR, PGR-2, PGR1, prostaglandin 13-reductase, prostaglandin DELTA13-reductase, prostaglandin reductase 1, reductase, 15-oxo-DELTA13-prostaglandin

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.48 13,14-dehydro-15-oxoprostaglandin 13-reductase

Inhibitors

Inhibitors on EC 1.3.1.48 - 13,14-dehydro-15-oxoprostaglandin 13-reductase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
13,14-dihydro-15-prostaglandin E2
-
competitive product inhibition
15-keto prostaglandin F2alpha
-
43.06% residual activity at 0.1 mM
5-(2-chloro-3-((4-methylcyclohexyl)methoxy)benzylidene)-1,3-thiazolidine-2,4-dione
-
-
-
5-(2-chloro-3-((5-oxo-5,6,7,8-tetrahydronaphthalen-1-yl)oxy)benzylidene)-1,3-thiazolidine-2,4-dione
-
-
5-(2-chloro-3-(1-cyclopropylethoxy)benzylidene)-1,3- thiazolidine-2,4-dione
-
-
5-(2-chloro-3-(2-(4-methyl-1,3-thiazolidin-5-yl)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
-
-
5-(2-chloro-3-(2-(cyclohexyloxy)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
-
-
5-(2-chloro-3-(2-(propan-2-yloxy)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
-
-
5-(2-chloro-3-(2-(pyridin-2-yl)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
-
-
5-(2-chloro-3-(2-cyclohexylethoxy)benzylidene)thiazolidine-2,4-dione
-
-
5-(2-chloro-3-(2-cyclopentylethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
-
-
5-(2-chloro-3-(3-cyclohexylpropoxy)benzylidene)thiazolidine-2,4-dione
-
-
5-(2-chloro-3-(3-nitrophenoxy)benzylidene)-1,3-thiazolidine-2,4-dione
-
-
5-(2-chloro-3-(3-phenylpropoxy)benzylidene)thiazolidine-2,4-dione
-
the compound significantly increases the level of PGE2 in skin defects
5-(2-chloro-3-(4-cyclohexylbutoxy)benzylidene)thiazolidine-2,4-dione
-
-
5-(2-chloro-3-(4-nitrobenzyloxy)benzylidene)thiazolidine-2,4-dione
-
-
5-(2-chloro-3-(4-phenylbutoxy)benzylidene)thiazolidine-2,4-dione
-
-
5-(2-chloro-3-(cyclobutylmethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
-
-
5-(2-chloro-3-(cyclohexylmethoxy)benzylidene)thiazolidine-2,4-dione
-
-
5-(2-chloro-3-(cyclohexyloxy)benzylidene)thiazolidine-2,4-dione
-
-
5-(2-chloro-3-(cyclopentylmethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
-
-
5-(2-chloro-3-(cyclopentyloxy)benzylidene)-1,3-thiazolidine-2,4-dione
-
-
5-(2-chloro-3-phenethoxybenzylidene)thiazolidine-2,4-dione
-
-
5-(3-(benzyloxy)-2-chlorobenzylidene)thiazolidine-2,4-dione
-
-
5-(3-(bicyclo[2.2.1]hept-2-ylmethoxy)-2-chlorobenzylidene)-1,3-thiazolidine-2,4-dione
-
-
benzylidene acetophenone
-
21.09% residual activity at 0.5 mM
Cibacron blue 3 G-A
ciglitazone
-
-
dicoumarol
Disulfiram
-
0.1 mM, 61% inhibition, cofactor NADPH, substrate 15-ketoprostaglandin E2
indomethacin
NADH
-
uncompetitive inhibition at high concentrations
NADPH
p-chloromercuribenzoate
quercitrin
thiazolidinedione
-
-
additional information
-