1.3.1.48: 13,14-dehydro-15-oxoprostaglandin 13-reductase

This is an abbreviated version!
For detailed information about 13,14-dehydro-15-oxoprostaglandin 13-reductase, go to the full flat file.

Reaction

Synonyms

15-hydroxyprostaglandin dehydrogenase, 15-keto-PG reductase, 15-ketoprostaglandin DELTA-13-reductase, 15-ketoprostaglandin DELTA13-reductase, 15-ketoprostaglandinDELTA13-reductase, 15-oxoprostaglandin 13-oxidase, 15-oxoprostaglandin 13-reductase, 15-oxoprostaglandin DELTA13-reductase, 15-oxoprostaglandin-DELTA13-reductase, 15-PGDH, Ad-PGR, bifunctional leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase, bifunctional LTB4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase, DELTA13-15-ketoprostaglandin reductase, leukotriene B4 12-hydroxydehydrogenase/15-ketoprostaglandin 13-reductase, leukotriene B4 dehydrogenase, leukotriene B4-12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase, LTB4 12-HD/PGR, LTBDH/PGR, NAD(P)H-dependent alkenal/one oxidoreductase, PG reductase, PGR, PGR-2, PGR1, prostaglandin 13-reductase, prostaglandin DELTA13-reductase, prostaglandin reductase 1, reductase, 15-oxo-DELTA13-prostaglandin

ECTree

     1 Oxidoreductases

         1.3 Acting on the CH-CH group of donors

             1.3.1 With NAD⁺ or NADP⁺ as acceptor

                1.3.1.48 13,14-dehydro-15-oxoprostaglandin 13-reductase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
2927	AA Sequence
1	CAS Registry Number
9	Cloned(Commentary)
21	Cofactor
3	Crystallization (Commentary)
35	Disease/ Diagnostics
3	General Information
22	IC50 Value
55	Inhibitors
5	Ki Value [mM]
72	KM Value [mM]
3	Localization
1	Metals/Ions
9	Molecular Weight [Da]
10	Natural Substrates/ Products (Substrates)
21	Organism
6	Pathway
22	PDB ID
3	pH Optimum
2	pH Range
13	Purification (Commentary)
1	Reaction
4	Reaction Type
21	Reference
31	Source Tissue
22	Specific Activity [micromol/min/mg]
8	Storage Stability
123	Substrates and Products (Substrate)
3	Subunits
31	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
28	Turnover Number [1/s]

General Information

print visible entries

print all entries

General Information on EC 1.3.1.48 - 13,14-dehydro-15-oxoprostaglandin 13-reductase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to General Information Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

evolution

Homo sapiens

P15428

the three human PG reductases are zinc-independent members of the medium-chain dehydrogenase/reductase (MDR) superfamily

744677

metabolism

Homo sapiens

P15428

prostaglandins are lipid compounds derived from arachidonic acid by the action of cyclooxygenases, acting locally as messenger molecules in a wide variety of physiological processes, such as inflammation, cell survival, apoptosis, smooth muscle contraction, adipocyte differentiation, vasodilation and platelet aggregation inhibition. In the inactivating pathway of prostaglandins, the first metabolic intermediates are 15-keto-prostaglandins, which are further converted into 13,14-dihydro-15-keto-prostaglandins by different enzymes having 15-keto-prostaglandin reductase activity

744677

physiological function

Homo sapiens

-

prostaglandin E2, PGE2, has a short half-life in vivo because is rapidly oxidized to 15-ketoprostaglandins by the cytosolic enzyme 15-PGDH. PGE2 acts through EP2 and EP4 receptors to mediate regeneration and hematopoietic stem cell development via the Wnt signaling pathway. Wnt activation in stem cells requires PGE2, and the PGE2/Wnt interaction is a master regulator of vertebrate regeneration and recovery. PGE2 regulates vertebrate hematopoietic stem cell induction and engraftment

746356