1.3.1.45: 2'-hydroxyisoflavone reductase

This is an abbreviated version!
For detailed information about 2'-hydroxyisoflavone reductase, go to the full flat file.

Word Map on EC 1.3.1.45

Reaction

vestitone
+
NADP+
=
2'-hydroxyformononetin
+
NADPH
+
H+

Synonyms

CaIRL, GbIRL1, GmIFR, IFR, IRL, isoflavone reductase, isoflavone reductase-like protein, LOC100786578, More, NADPH:2'-hydroxyisoflavone oxidoreductase, Ole e 12, OsIRL, PvIFR1, reductase, 2',7-dihydroxy-4',5'-methylenedioxyisoflavone, reductase, 2'-hydroxyisoflavone

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.45 2'-hydroxyisoflavone reductase

Engineering

Engineering on EC 1.3.1.45 - 2'-hydroxyisoflavone reductase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D285G
-
decreased turnover rate
DELTA39-47
-
nine of the amino acid residues around position 40 deleted in the current construct D39-47 IFR to facilitate crystallization, affects enzyme activity only slightly
G14F
-
no detectable activity
H164A
-
decreased turnover rate
K144A
-
complete loss of enzyme activity
R97G
-
decreased turnover rate
Y169A
-
decreased turnover rate
Y272A
-
decreased turnover rate
additional information