1.3.1.44: trans-2-enoyl-CoA reductase (NAD+)
This is an abbreviated version!
For detailed information about trans-2-enoyl-CoA reductase (NAD+), go to the full flat file.
Word Map on EC 1.3.1.44
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1.3.1.44
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clostridium
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biofuels
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acetobutylicum
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treponema
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denticola
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1-butanol
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butyryl-coa
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crotonase
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euglena
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gracilis
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enoyl-coas
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acyl-coas
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thiolase
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propionyl-coa
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ferredoxins
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coa-dependent
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longer-chain
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enoyl-acyl
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feedstock
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medicine
- 1.3.1.44
- clostridium
-
biofuels
- acetobutylicum
-
treponema
- denticola
- 1-butanol
- butyryl-coa
- crotonase
- euglena
- gracilis
- enoyl-coas
- acyl-coas
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thiolase
- propionyl-coa
- ferredoxins
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coa-dependent
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longer-chain
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enoyl-acyl
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feedstock
- medicine
Reaction
Synonyms
2-enoyl-reductase, BatG, CaTER, crotonyl-CoA reductase, NAD-linked, EgTER1, enoyl-acyl carrier protein reductase, ENR, FabI, More, Tde_0597, tdTer, TER, trans-2-enoyl-ACP reductase, trans-2-enoyl-ACP(CoA) reductase, trans-2-enoyl-CoA reductase, trans-2-enoyl-CoA reductase, NADH-dependent, trans-2-enoyl-CoA reductases, trans-enoyl-CoA reductase
ECTree
1.3.1.44 trans-2-enoyl-CoA reductase (NAD+)Advanced search results
results (
results (Substrates Products
Substrates Products on EC 1.3.1.44 - trans-2-enoyl-CoA reductase (NAD+)
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
trans-didehydroacyl-CoA + NAD(P)H
acyl-CoA + NAD(P)+
i.e. enoyl-CoA
-
-
?
(E)-2-hexanoyl-CoA + NADPH
hexanoyl-CoA + NADP+
-
-
-
?
acyl-CoA + NAD+
trans-2,3-didehydroacyl-CoA + NADH
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contributes to fatty acid synthesis beta-oxidation in mitochondria
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-
?
acyl-CoA + NAD+
trans-2,3-didehydroacyl-CoA + NADH
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fatty acid elongation
-
-
?
crotonyl-CoA + NADH
butanoyl-CoA + NAD+
high activity toward crotonyl-CoA
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-
?
crotonyl-CoA + NADH
butanoyl-CoA + NAD+
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high activity toward crotonyl-CoA
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-
?
crotonyl-CoA + NADH
butyryl-CoA + NAD+
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negative cooperativity in the reaction with substrate
-
-
?
crotonyl-CoA + NADH + H+
butyryl-CoA + NAD+
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crotonyl-CoA is reduced to butyryl-CoA by NADH, but not by NADPH, only in the presence of flavin nucleotides (FMN or FAD)
-
-
?
crotonyl-CoA + NADPH + H+
butyryl-CoA + NADP+
NADPH is a poor cosubstrate
-
-
?
crotonyl-CoA + NADPH + H+
butyryl-CoA + NADP+
NADPH is a poor cosubstrate
-
-
?
hexenoyl-CoA + NADH
? + NAD+
weak activity toward crotonyl-CoA
-
-
?
hexenoyl-CoA + NADH
? + NAD+
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weak activity toward crotonyl-CoA
-
-
?
trans-2-decenoyl-CoA + NADH
decanoyl-CoA + NAD+
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reductase II: highest activity
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-
?
trans-2-dodecenoyl-CoA + NADH
dodecanoyl-CoA + NAD+
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-
i.e. laurate
?
trans-2-dodecenoyl-CoA + NADH + H+
dodecanoyl-CoA + NAD+
-
-
-
?
trans-2-hexadecenoyl-CoA + NADH
hexadecanoyl-CoA + NAD+
-
-
-
-
?
trans-2-hexenoyl-CoA + NAD(P)H
hexanoyl-CoA + NAD(P)+
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reductase III: highest activity, utilizes substrates of chain length C4-C12
-
-
?
trans-2-octenoyl-CoA + NADH
octanoyl-CoA + NAD+
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reductase II: highest activity
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-
?
additional information
?
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no activity with butanoyl-CoA
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-
?
additional information
?
-
-
reductase isoforms are chain length-specific
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-
?
additional information
?
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enzyme is involved in malonyl-CoA independent lipid synthesis and wax ester fermentation
-
-
?
additional information
?
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enzyme is involved in malonyl-CoA independent lipid synthesis and wax ester fermentation
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-
?
additional information
?
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inert to substrates with chain length below C8
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-
?
additional information
?
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inert to substrates with chain length below C8
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-
?
additional information
?
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rat hepatic microsomal long-chain and short-chain trans-2-enoyl-CoA reductases with cofactor requirement (NADH or NADPH) depending on substrate chain length are characterized. Since no cis-2-enoyl-CoA compounds are tested as substrates a classification according to EC 1.3.1.8, EC 1.3.1.38 or EC 1.3.1.44 is impossible
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?
