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1.3.1.38: trans-2-enoyl-CoA reductase (NADPH)

This is an abbreviated version!
For detailed information about trans-2-enoyl-CoA reductase (NADPH), go to the full flat file.

Wordmap for 1.3.1.38

Word Map on EC 1.3.1.38 Wordmap for 1.3.1.38

Reaction

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acyl-CoA
+
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NADP+
=
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trans-2,3-dehydroacyl-CoA
+
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NADPH
+
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H+

Synonyms

2-trans enoyl-ACP(CoA) reductase, ECR, EgTER1, enoyl reductase, InhA, MECR, MECR-1, mitochondrial 2-trans-enoyl-CoA/ACP reductase, mitochondrial 2-trans-enoyl-thioester reductase, NADPH-dependent trans-2-enoyl-CoA reductase, reductase, trans-enoyl coenzyme A, TER, trans-2-enoyl-CoA reductase, trans-2-enoyl-CoA reductase (NADPH)

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                EC 1.3.1.381.3.1.38 trans-2-enoyl-CoA reductase (NADPH)

Engineering

Engineering on EC 1.3.1.38 - trans-2-enoyl-CoA reductase (NADPH)

for references in articles please use BRENDA:EC1.3.1.38

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
G225A
upon expression in Saccharomyces cerevisiae tsc13DELTA mutant significant accumulation of fatty acids C22:0, C20:0, C18:0, C18-OH, and especially C16-OH is detected
G227A
similar to wild-type
G228A
similar to wild-type
G234A
upon expression in Saccharomyces cerevisiae tsc13DELTA mutant significant accumulation of fatty acids C22:0, C20:0, C18:0, C18-OH, and especially C16-OH is detected
I231A
upon expression in Saccharomyces cerevisiae tsc13DELTA mutant significant accumulation of fatty acids C22:0, C20:0, C18:0, C18-OH, and especially C16-OH is detected
P232A
upon expression in Saccharomyces cerevisiae tsc13DELTA mutant significant accumulation of fatty acids C22:0, C20:0, C18:0, C18-OH, and especially C16-OH is detected
Q230A
similar to wild-type
R233A
similar to wild-type
S226A
similar to wild-type
Y229A
similar to wild-type
P182L
-
the mutant exhibits lower trans-2-enoyl-CoA reductase activity as compared with the wild type enzyme
F149A
-
the mutant is not able to optimally position the cofactor for hydride transfer, which correlates with the 30fold decrease in kcat
K165A
-
normal expression in Escherichia coli
K165Q
-
normal expression in Escherichia coli
Y158F
-
expression in Escherichia coli sub-population BL21(DE3)NH
additional information