1.3.1.34: 2,4-dienoyl-CoA reductase (NADPH)

This is an abbreviated version!
For detailed information about 2,4-dienoyl-CoA reductase (NADPH), go to the full flat file.

Word Map on EC 1.3.1.34

Reaction

trans-2,3-didehydroacyl-CoA
+
NADP+
=
trans,trans-2,3,4,5-tetradehydroacyl-CoA
+
NADPH
+
H+

Synonyms

2,4-dienoyl coenzyme A reductase, 2,4-dienoyl-CoA reductase, 2,4-dienoyl-CoA reductase [NADPH], 4-enoyl-CoA reductase, 4-enoyl-CoA reductase (NADPH), 4-enoyl-CoA reductase [NADPH], DCR, DECR, More, pDCR, peroxisomal 2,4-dienoyl CoA reductase, SDR, short-chain dehydrogenase

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.34 2,4-dienoyl-CoA reductase (NADPH)

KM Value

KM Value on EC 1.3.1.34 - 2,4-dienoyl-CoA reductase (NADPH)

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0127
(2E,4E)-2,4-decadienoyl-CoA
-
pH 7.4, 20°C
0.0716
(2E,4E)-2,4-hexadienoyl-CoA
-
pH 7.4, 20°C
0.102 - 0.155
2,4,7,10,13,16,19-docosaheptaenoyl-CoA
0.006
2,4-decadienoyl-CoA
0.059 - 0.108
2,4-hexadienoyl-CoA
0.0062
2,4-trans-decadienoyl-CoA
-
recombinant His-tagged truncated enzyme, pH 6.0, 22°C
0.0265
2,4-trans-hexadienoyl-CoA
-
recombinant His-tagged truncated enzyme, pH 6.0, 22°C
0.0065
2-fluoro-trans-trans-2,4-octadienoyl-CoA
-
recombinant His-tagged truncated wild-type enzyme, pH 6.0, 22°C
0.0023
2-trans,4-trans-decadienoyl-CoA
-
-
0.00046
2-trans,4-trans-hexadienoyl-CoA
-
-
0.016
5-methyl-trans-trans-2,4-hexadienoyl-CoA
-
recombinant His-tagged truncated wild-type enzyme, pH 6.0, 22°C
0.00044 - 0.215
NADPH
0.0045 - 0.154
trans-trans-2,4-hexadienoyl-CoA
additional information
additional information
-
kinetics of oleoyl-CoA degradation in mitochondrial protein extract
-