1.3.1.3: DELTA4-3-oxosteroid 5beta-reductase

This is an abbreviated version!
For detailed information about DELTA4-3-oxosteroid 5beta-reductase, go to the full flat file.

Word Map on EC 1.3.1.3

1.3.1.3

bile

chenodeoxycholic

digitalis

akr1c4

cardenolide

lanata

bile-acids

cyp7b1

delta4-3-ketosteroids

tocolytic

srd5a1

pre-receptor

medicine

Reaction

17,21-dihydroxy-5beta-pregnane-3,11,20-trione

Synonyms

3-oxo-DELTA4-steroid 5beta-reductase, 4,5beta-dihydrocortisone:NADP+ DELTA4-oxidoreductase, 5-beta-reductase, 5beta-POR, 5beta-red, AKR1D1, AKR1D4, aldo-keto reductase, aldo-keto reductase 1D1, aldo�keto reductase 1D1, androstenedione 5beta-reductase, CARUB_v10005016mg, cortisone 5beta-reductase, cortisone beta-reductase, DELTA 4-5beta-reductase, DELTA4-3-ketosteroid 5beta-reductase, DELTA4-3-oxosteroid 5beta-reductase, DELTA4-hydrogenase, EC 1.3.1.23, EC 1.3.1.3, h5beta-red, h5beta-reductase, More, P5betaR, progesterone 5beta-reductase, reductase, cholestenone 5beta.-, reductase, cortisone DELTA4-5beta-, SRD5beta, St5betaR1, steroid 5beta-reductase, steroid 5beta.-reductase, testosterone 5-beta-reductase, testosterone 5beta-reductase

ECTree

1 Oxidoreductases

1.3 Acting on the CH-CH group of donors

1.3.1 With NAD⁺ or NADP⁺ as acceptor

1.3.1.3 DELTA4-3-oxosteroid 5beta-reductase

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Results	in table
37	AA Sequence
5	Application
2	CAS Registry Number
20	Cloned(Commentary)
27	Cofactor
9	Crystallization (Commentary)
96	Disease/ Diagnostics
6	Expression
11	General Information
4	General Stability
30	Inhibitors
43	kcat/KM [mM/s]
5	Ki Value [mM]
78	KM Value [mM]
9	Localization
7	Molecular Weight [Da]
27	Natural Substrates/ Products (Substrates)
45	Organism
6	Pathway
34	PDB ID
14	pH Optimum
3	pH Range
1	pH Stability
1	pI Value
49	Protein Variants
18	Purification (Commentary)
6	Reaction
6	Reaction Type
43	Reference
29	Source Tissue
10	Specific Activity [micromol/min/mg]
4	Storage Stability
123	Substrates and Products (Substrate)
7	Subunits
67	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
2	Temperature Stability [°C]
53	Turnover Number [1/s]

KM Value

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KM Value on EC 1.3.1.3 - DELTA4-3-oxosteroid 5beta-reductase

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0.0032

1,4-androstadien-17beta-ol-3-one

Homo sapiens

pH 6.0, 37°C

726492

0.116 - 1.15

2-cyclohexen-1-one

9 entries

0.0009 - 2.193

4-androstene-3,17-dione

7 entries

0.0008

4-cholesten-7alpha-ol-3-one

Homo sapiens

pH 6.0, 37°C

726492

0.003

4-estren-17beta-ol-3-one

Homo sapiens

pH 6.0, 37°C

726492

0.0122

7alpha,12alpha-dihydroxy-4-cholesten-3-one

Rattus norvegicus

390591

0.0091

7alpha-hydroxy-4-cholesten-3-one

Rattus norvegicus

390591

0.0025

aldosterone

Homo sapiens

pH 6.0, 37°C

726492

0.022

androst-4-en-3,17-dione

Mus musculus

390593

0.0022

androst-4-ene-3,17-dione

Mus musculus

390593

0.00037 - 0.01629

androstenedione

3 entries

0.0003

cholestenone

Homo sapiens

pH 6.0, 37°C

726492

1.597 - 2.373

cortexone

2 entries

0.0022

corticosterone

Homo sapiens

pH 6.0, 37°C

726492

0.0071 - 2.079

cortisol

6 entries

0.0013 - 0.034

cortisone

8 entries

0.0029

Epitestosterone

Homo sapiens

pH 6.0, 37°C

726492

0.003 - 0.085

NADPH

7 entries

0.00219 - 0.362

progesterone

14 entries

0.0016 - 0.0127

testosterone

9 entries

additional information

4 entries