1.3.1.3: DELTA4-3-oxosteroid 5beta-reductase This is an abbreviated version! For detailed information about DELTA4-3-oxosteroid 5beta-reductase, go to the full flat file .
Reaction
17,21-dihydroxy-5beta-pregnane-3,11,20-trione +
NADP+ =
cortisone +
NADPH +
H+
Synonyms 3-oxo-DELTA4-steroid 5beta-reductase, 4,5beta-dihydrocortisone:NADP+ DELTA4-oxidoreductase, 5-beta-reductase, 5beta-POR, 5beta-red, AKR1D1, AKR1D4, aldo-keto reductase, aldo-keto reductase 1D1, aldo–keto reductase 1D1, androstenedione 5beta-reductase, CARUB_v10005016mg, cortisone 5beta-reductase, cortisone beta-reductase, DELTA 4-5beta-reductase, DELTA4-3-ketosteroid 5beta-reductase, DELTA4-3-oxosteroid 5beta-reductase, DELTA4-hydrogenase, EC 1.3.1.23, EC 1.3.1.3, h5beta-red, h5beta-reductase, More, P5betaR, progesterone 5beta-reductase, reductase, cholestenone 5beta.-, reductase, cortisone DELTA4-5beta-, SRD5beta, St5betaR1, steroid 5beta-reductase, steroid 5beta.-reductase, testosterone 5-beta-reductase, testosterone 5beta-reductase
ECTree
Inhibitors
Inhibitors on EC 1.3.1.3 - DELTA4-3-oxosteroid 5beta-reductase
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17beta-hydroxy-5alpha-androstan-3-one
-
0.01 mM, 57% inhibition
17beta-hydroxy-5beta-androstan-3-one
-
0.01 mM, 28% inhibition
4-benzoylbenzoic acid
-
-
5beta-dihydrotestosterone
-
product inhibition
Cu2+
-
0.5 mM 66% inhibition
estradiol-17beta
-
0.01 mM, 29% inhibition
estrone
-
0.01 mM, 29% inhibition
Hg2+
-
0.1 mM, 92% inhibition
NADP+
-
product inhibition
p-chloromercuribenzenesulfonate
-
-
p-Chloromercuribenzyl sulfonate
-
2 mM, complete inhibition, 50% inhibition in the presence of 10 mM glutathione
androstenedione
the enzyme is rapidly inhibited by the substrate once its concentration reaches 2times the Km value. Androstenedione completely impedes the passage of another substrate molecule toward the catalytic site
androstenedione
-
0.01 mM, 93% inhibition
chenodeoxycholic acid
-
-
chenodeoxycholic acid
-
competitively inhibits 5beta-reductase
p-chloromercuribenzoate
-
0.1 mM, 95% inhibition
p-chloromercuribenzoate
-
-
p-chloromercuribenzoate
-
-
progesterone
the enzyme is rapidly inhibited by the substrate once its concentration reaches 2times the Km value
progesterone
-
0.002 mM, 84% inhibition
testosterone
-
-
testosterone
substrate inhibition; substrate inhibition of the wild-type enzyme
additional information
structural features of substrate inhibition of h5beta-red by C19- and C21-steroids, overview
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additional information
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structural features of substrate inhibition of h5beta-red by C19- and C21-steroids, overview
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additional information
-
substrate inhibition is observed with C18 to C21 steroids provided that the C11 position is unsubstituted
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