1.3.1.24: biliverdin reductase
This is an abbreviated version!
For detailed information about biliverdin reductase, go to the full flat file.
Word Map on EC 1.3.1.24
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1.3.1.24
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heme
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oxygenase-1
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monoxide
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cytoprotective
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repolarization
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beat-to-beat
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rosenthal
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hyperbilirubinemia
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palliation
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tetrapyrrole
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tdp
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torsades
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diagnostics
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proarrhythmia
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medicine
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galenic
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univentricular
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pharmacology
- 1.3.1.24
- heme
- oxygenase-1
-
monoxide
-
cytoprotective
-
repolarization
-
beat-to-beat
-
rosenthal
-
hyperbilirubinemia
-
palliation
- tetrapyrrole
- tdp
-
torsades
- diagnostics
-
proarrhythmia
- medicine
-
galenic
-
univentricular
- pharmacology
Reaction
Synonyms
biliverdin IXalpha reductase, biliverdin IXbeta reductase, biliverdin reductase, biliverdin reductase A, biliverdin reductase B, Biliverdin reductase-A, biliverdin-IXalpha reductase, BLVR subtype B, BLVRA, BLVRB, BV reductase, BVR, BVR-A, BVR-B, BVRA, BVRB, F-BVR, F420H2-dependent biliverdin reductase, hBVR, hBVR-A, reductase, biliverdin, Rv2074, slr1784
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Natural Substrates Products
Natural Substrates Products on EC 1.3.1.24 - biliverdin reductase
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REACTION DIAGRAM
biliverdin IXalpha + NADH + H+
bilirubin IXalpha + NAD+
substrate for isoform BVRA
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r
biliverdin IXalpha + NADPH + H+
bilirubin IXalpha + NADP+
substrate for isoform BVRA
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r
biliverdin IXbeta + NADH + H+
bilirubin IXbeta + NAD+
substrate for isoform BVRB
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r
biliverdin IXbeta + NADPH + H+
bilirubin IXbeta + NADP+
substrate for isoform BVRB
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r
biliverdin + NADPH + H+
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r
bilirubin + reduced coenzyme F420
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?
biliverdin + coenzyme F420 + H+
bilirubin + reduced coenzyme F420
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bilirubin + NAD(P)+
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physiologic degradation of heme to bile pigments
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?
biliverdin + NAD(P)H
bilirubin + NAD(P)+
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physiologic degradation of heme to bile pigments
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?
biliverdin + NAD(P)H
bilirubin + NAD(P)+
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physiologic degradation of heme to bile pigments
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?
biliverdin + NAD(P)H
bilirubin + NAD(P)+
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physiologic degradation of heme to bile pigments
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?
biliverdin + NAD(P)H
bilirubin + NAD(P)+
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importance in linear tetrapyrrole metabolism
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enzyme advances the role of heme oxidase 1 in cytoprotection and also affords cytoprotection independent of heme degradation
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additional information
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enzyme may be an essential component of normal physiologic gastrointestinal defense
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additional information
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enzyme physiologically regenerates bilirubin in a catalytic cycle, providing antioxidant cytoprotection
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additional information
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role of enzyme in regulation of activating protein 1 and cAMP-regulated genes and in cell signaling
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additional information
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the enzyme shows dual cofactor- and pH-dependency in activity
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additional information
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hBVR binds to Goodpasture antigen-binding protein and down-regulates its TNF-alpha-stimulated kinase activity
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additional information
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enzyme diverts tetrapyrrole metabolism toward heme synthesis while also reducing heme levels to de-repress synthesis of 5-aminolevulinic acid
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additional information
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the enzyme shows dual cofactor- and pH-dependency in activity
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additional information
?
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enzyme may be an essential component of normal physiologic gastrointestinal defense
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?