1.3.1.24: biliverdin reductase
This is an abbreviated version!
For detailed information about biliverdin reductase, go to the full flat file.
Word Map on EC 1.3.1.24
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1.3.1.24
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heme
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oxygenase-1
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monoxide
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cytoprotective
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repolarization
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beat-to-beat
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rosenthal
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hyperbilirubinemia
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palliation
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tetrapyrrole
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tdp
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torsades
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diagnostics
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proarrhythmia
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medicine
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galenic
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univentricular
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pharmacology
- 1.3.1.24
- heme
- oxygenase-1
-
monoxide
-
cytoprotective
-
repolarization
-
beat-to-beat
-
rosenthal
-
hyperbilirubinemia
-
palliation
- tetrapyrrole
- tdp
-
torsades
- diagnostics
-
proarrhythmia
- medicine
-
galenic
-
univentricular
- pharmacology
Reaction
Synonyms
biliverdin IXalpha reductase, biliverdin IXbeta reductase, biliverdin reductase, biliverdin reductase A, biliverdin reductase B, Biliverdin reductase-A, biliverdin-IXalpha reductase, BLVR subtype B, BLVRA, BLVRB, BV reductase, BVR, BVR-A, BVR-B, BVRA, BVRB, F-BVR, F420H2-dependent biliverdin reductase, hBVR, hBVR-A, reductase, biliverdin, Rv2074, slr1784
ECTree
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Inhibitors
Inhibitors on EC 1.3.1.24 - biliverdin reductase
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biliverdin IXalpha
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with cofactor NADPH, inhibitory above 0.004 mM, with cofactor NADH, inhibitory above 0.018 mM
Protein phosphatase 2A
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human bilverdin reductase expressed in E. coli, okadaic acid attenuates the inhibition
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SH-reactive agent
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34000 Da form extremely sensitive to, larger 68000 Da form lacks sensitivity to
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additional information
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since no specific inhibitors for BVR are known, siRNA is used to silence the BVR gene in primary endothelial cells and accordingly suppress its activity
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5,5'-dithiobis(2-nitrobenzoate)
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pretreatment of the enzyme with NADPH and biliverdins fully protects
bilirubin
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inhibits the enzyme in a feedback regulation system, biliverdin inhibits the heme oxygenase activity, overview
Biliverdin
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the enzyme is inhibited by the substrate when the concentration exceeds 0.004-0.005 mM
iodoacetamide
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pretreatment of the enzyme with NADPH and biliverdins fully protects
N-ethylmaleimide
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pretreatment of the enzyme with NADPH and biliverdins fully protects
N-ethylmaleimide
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only one of three thiol residues can be alkylated when a ratio N-ethylmaleimide/mol enzyme SH = 90 is used, at a ratio of 300 two thiol residues are alkylated
p-chloromercuribenzoate
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pretreatment of the enzyme with NADPH and biliverdins fully protects
SH-reagents
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e.g. 5,5'-dithiobis(2-nitrobenzoic acid), N-ethylmaleimide, pretreatment of the enzyme with NADPH and biliverdins fully protects
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