1.3.1.22: 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+), go to the full flat file.

Word Map on EC 1.3.1.22

Reaction

a 3-oxo-5alpha-steroid
+
NADP+
=
a 3-oxo-DELTA4-steroid
+
NADPH
+
H+

Synonyms

3-oxosteroid 5alpha-reductase, 3-oxosteroid DELTA4-dehydrogenase, 4-ene-3-oxosteroid 5alpha-reductase, 4-ene-5alpha-reductase, 5 alpha-R2, 5 alpha-reductase type 2, 5-alpha reductase I, 5-alpha reductase II, 5-alpha-reductase type 1, 5-alpha-reductase type 2, 5a-reductase type 1, 5a-reductase type 2, 5A2, 5alpha-R1, 5alpha-R2, 5alpha-reductase 1, 5alpha-reductase II, 5alpha-reductase type 1, 5alpha-reductase type 2, 5alpha-reductase type II, 5alpha-SR2, 5alphaR, 5alphaR type 2, 5alphaR1, 5alphaR2, AtDET2, cholest-4-en-3-one 5alpha-reductase, cortisone alpha-reductase, cortisone DELTA 4-5alphareductase, DELTA4-3-ketosteroid 5alpha-oxidoreductase, DELTA4-3-ketosteroid reductase (5alpha), DELTA4-3-oxosteroid-5 alpha-reductase, DELTA4-5alpha-reductase, DELTA4-steroid 5alpha-reductase (progesterone), LeDET2, microsomal steroid reductase (5alpha), More, NADPH:DELTA4-3-oxosteroid-5alpha-oxidoreductase, progesterone 5alpha-reductase, reduced nicotinamide adenine dinucleotide phosphate:DELTA4-3-ketosteroid 5alpha-oxidoreductase, reductase, cholestenone 5alpha-, reductase, cortisone DELTA: 4-5alpha-, reductase, progesterone 5alpha-, S5alphaR, SRD5A2, SRDA1, SRDA2, SRDA3, steroid 5-alpha reductase, steroid 5-alpha-reductase, steroid 5alpha reductase type 2, steroid 5alpha-hydrogenase, steroid 5alpha-reductase, testosterone 5alpha-reductase, testosterone delta4-5alpha-reductase, testosterone delta4-hydrogenase, type 1 5alpha-reductase, type 1 5alphaR, type 1 SR, type 1 steroid 5alpha reductase, type 1 steroid 5alpha-reductase, type 2 5alpha-reductase, type 2 5alphaR, type 2 SR, type 2 steroid 5alpha reductase, type 2 steroid 5alpha-reductase, type-1 5alpha-reductase, type-2 5alpha-reductase

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.22 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)

pH Optimum

pH Optimum on EC 1.3.1.22 - 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)

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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.2 - 5.6
-
mutant G34R
5.5 - 7.5
-
-
5.5
-
isozyme 2, low substrate concentration, efficiency optimum Vmax/Km
5.7
-
in testis microsomes of 5 month-old animals
5.8 - 7.5
-
-
6 - 6.5
-
mutant P181L
6.2
-
female
6.3
-
in testis microsomes of 6 month-old animals
7 - 9
-
human: 2 forms, 1. pH-optimum 5.5 (only in fibroblasts derived from genital skin), 2. pH-optimum 7-9 (in both genital and nongenital skin regions and in fibroblast from all skin regions)
7.3 - 7.6
-
-
8
-
recombinant monkey 5alpha-reductase isozyme 1