1.3.1.20: trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
This is an abbreviated version!
For detailed information about trans-1,2-dihydrobenzene-1,2-diol dehydrogenase, go to the full flat file.
Word Map on EC 1.3.1.20
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1.3.1.20
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dihydrodiol
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trans-dihydrodiols
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medicine
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polycyclic
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catechols
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nadp+-dependent
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benzenedihydrodiol
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indomethacin
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penning
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alpha-hydroxysteroids
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o-quinones
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talalay
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anti-diol
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1.1.1.184
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+/-trans-7,8-dihydroxy-7,8-dihydrobenzoapyrene
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non-k-region
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benzaanthracene
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alicyclic
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trans-1,2-dihydrodiols
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dicoumarol
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chrysene
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benzoapyrene-7,8-dione
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harvey
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pah-induced
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androsterone
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diagnostics
- 1.3.1.20
- dihydrodiol
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trans-dihydrodiols
- medicine
-
polycyclic
- catechols
-
nadp+-dependent
- benzenedihydrodiol
- indomethacin
-
penning
-
alpha-hydroxysteroids
- o-quinones
-
talalay
-
anti-diol
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1.1.1.184
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+/-trans-7,8-dihydroxy-7,8-dihydrobenzoapyrene
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non-k-region
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benzaanthracene
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alicyclic
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trans-1,2-dihydrodiols
- dicoumarol
- chrysene
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benzoapyrene-7,8-dione
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harvey
-
pah-induced
- androsterone
- diagnostics
Reaction
Synonyms
AKR1C1, AKR1C2, DD, DDH, DDH1, DDH2, dehydrogenase, trans-1,2-dihydrobenzene-1,2-diol, DHDH, dihydrodiol dehydrogenase, More
ECTree
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Natural Substrates Products
Natural Substrates Products on EC 1.3.1.20 - trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
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REACTION DIAGRAM
5alpha-dihydrotestosterone + NADPH + H+
5alpha-androstan-3alpha,17beta-diol + NADP+
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r
camphorquinone + NADPH + H+
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enzyme has dehydrogenase and reductase activities, enzyme is identical to NADP+-dependent D-xylose dehydrogenase
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trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+
catechol + NAD(P)H
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trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+
catechol + NAD(P)H
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metabolic inactivation of exogeneous xenobiotics
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additional information
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involved in the metabolism of steroid hormones and polycyclic aromatic hydrocarbons, and also in the reduction of ketone-containing drugs
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additional information
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involved in the metabolism of steroid hormones and polycyclic aromatic hydrocarbons, and also in the reduction of ketone-containing drugs
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additional information
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enzyme-mediated oxidative damage is involved in the hydroxychavicol and benzo[a]pyrene-induced toxic effects
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additional information
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the enzyme is a member of the aldo-keto reductase superfamily, which normally reduces polycyclic aromatic hydrocarbons in the liver, it plays an important role in detoxification
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additional information
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dihydrodiol dehydrogenase catalyzes the NADP+-linked oxidation of dihydrodiols of aromatic hydrocarbons to their corresponding catechols and is regarded as a toxication enzyme in the metabolism of carcinogenic polycyclic aromatic hydrocarbons because oxidation by the enzyme yields reactive and redox-active ortho-quinones and reactive oxygen species, broad substrate specificity indicates additional roles of the enzyme in the metabolism of endogenous and xenobiotic carbonyl compounds and the prevention of the development of glycation
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additional information
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dimeric dihydrodiol dehydrogenase catalyses the nicotinamide adenine dinucleotide phosphate NADP+-dependent oxidation of trans-dihydrodiols of aromatic hydrocarbons to their corresponding catechols, dimeric dihydrodiol dehydrogenase is also competent in the NADPH-driven reduction of a limited number of aldehyde and dicarbonyl compounds such as 3-deoxyglucosone, camphorquinone, and 3-nitrobenzaldehyde
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additional information
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metabolic inactivation of dihydrodiols or dihydrodiol epoxides derived from carcinogenic polycylic hydrocarbons
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additional information
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enzyme catalyzes formation of benz[a]anthracene-1,2-dihydrodiol which causes Cu[II]-mediated DNA damage including 8-oxo-7,8-dihydro-2-deoxyguanosine formation in the presence of NAD+
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additional information
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reduces biologically important 3-oxo steroids of the androstane, pregnane, and cholane series
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additional information
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detoxification of polycyclic aromatic trans-hydrodiols by formation of o-quinones from the reaction product of dihydrodiol oxidation
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