1.3.1.2: dihydropyrimidine dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about dihydropyrimidine dehydrogenase (NADP+), go to the full flat file.

Word Map on EC 1.3.1.2

Reaction

5,6-dihydrouracil
+
NADP+
=
Uracil
+
NADPH
+
H+

Synonyms

4,5-dihydrothymine: oxidoreductase, dehydrogenase, dihydrouracil (nicotinamide adenine dinucleotide phosphate), DHPDH, DHPDHase, DHU dehydrogenase, dihydropyrimidine dehydrogenase, dihydrothymine dehydrogenase, Dihydrouracil dehydrogenase, dihydrouracil dehydrogenase (NADP), dihydrouracil dehydrogenase (NADP+), DPD, DPYD, hydropyrimidine dehydrogenase

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.2 dihydropyrimidine dehydrogenase (NADP+)

Disease

Disease on EC 1.3.1.2 - dihydropyrimidine dehydrogenase (NADP+)

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Breast Neoplasms
Antitumor effect of combination of S-1 and docetaxel on the human breast cancer xenograft transplanted into SCID mice.
Carcinoma, Hepatocellular
Dihydrouracil dehydrogenase activity in normal, differentiating and regnerating liver and in hepatomas.
Chickenpox
Inhibition of fluorouracil catabolism in cancer patients by the antiviral agent (E)-5-(2-bromovinyl)-2'-deoxyuridine.
dihydropyrimidine dehydrogenase (nadp+) deficiency
A screening method for dihydropyrimidine dehydrogenase deficiency with colorimetric detection of urinary uracil.
Acute confusion induced by a high-dose infusion of 5-fluorouracil and folinic acid.
Herpes Simplex
Inhibition of fluorouracil catabolism in cancer patients by the antiviral agent (E)-5-(2-bromovinyl)-2'-deoxyuridine.
Herpes Zoster
Inhibition of fluorouracil catabolism in cancer patients by the antiviral agent (E)-5-(2-bromovinyl)-2'-deoxyuridine.
Neoplasms
A phase II study of S-1 in patients with metastatic breast cancer--a Japanese trial by the S-1 Cooperative Study Group, Breast Cancer Working Group.
Antitumor effect of combination of S-1 and docetaxel on the human breast cancer xenograft transplanted into SCID mice.
Comparison of dihydropyrimidine dehydrogenase from human, rat, pig and cow liver. Biochemical and immunological properties.
Development of a novel form of an oral 5-fluorouracil derivative (S-1) directed to the potentiation of the tumor selective cytotoxicity of 5-fluorouracil by two biochemical modulators.
Effect of administration of 5-(phenylselenenyl)acyclouridine, an inhibitor of uridine phosphorylase, on the anti-tumor efficacy of 5-fluoro-2'-deoxyuridine against murine colon tumor C26-10.
Enzymes of uracil catabolism in normal and neoplastic human tissues.
Thiamine Deficiency
Acute confusion induced by a high-dose infusion of 5-fluorouracil and folinic acid.