1.3.1.15: dihydroorotate dehydrogenase (NADP+)

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For detailed information about dihydroorotate dehydrogenase (NADP+), go to the full flat file.

Reaction

Synonyms

reductase, orotate (reduced nicotinamide adenine dinucleotide phosphate), triphosphopyridine-linked dihydroorotic dehydrogenase

ECTree

     1 Oxidoreductases

         1.3 Acting on the CH-CH group of donors

             1.3.1 With NAD⁺ or NADP⁺ as acceptor

                1.3.1.15 dihydroorotate dehydrogenase (NADP+)

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Results	in table
1	AA Sequence
1	CAS Registry Number
4	Cofactor
5	Inhibitors
3	KM Value [mM]
1	Localization
1	Metals/Ions
2	Natural Substrates/ Products (Substrates)
2	Organism
2	pH Optimum
1	pH Range
1	Purification (Commentary)
1	Reaction
3	Reaction Type
2	Reference
1	Specific Activity [micromol/min/mg]
2	Storage Stability
4	Substrates and Products (Substrate)
2	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Stability [°C]
1	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 1.3.1.15 - dihydroorotate dehydrogenase (NADP+)

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

2,4-Dihydroxy-6-methylpyridine

Bacteria

-

7.8 mM, 22% inhibition

390571

5-Methylorotic acid

Bacteria

-

6 mM, 63% inhibition

390571

Barbituric acid

Bacteria

-

2 mM, 60% inhibition

390571

p-chloromercuribenzoate

Bacteria

-

0.01 mM, 90% inhibition, 0.001 mM, 30% inhibition

390571

Uracil-5-carboxylic acid

Bacteria

-

7.8 mM, 30% inhibition

390571