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Binds FMN, FAD and a [2Fe-2S] cluster. The enzyme consists of two subunits, an FMN binding catalytic subunit and a FAD and iron-sulfur binding electron transfer subunit . The reaction, which takes place in the cytosol, is the only redox reaction in the de-novo biosynthesis of pyrimidine nucleotides. Other class 1 dihydroorotate dehydrogenases use either fumarate (EC 188.8.131.52) or NADP+ (EC 184.108.40.206) as electron acceptor. The membrane bound class 2 dihydroorotate dehydrogenase (EC 220.127.116.11) uses quinone as electron acceptor.