1.3.1.14: dihydroorotate dehydrogenase (NAD+)

This is an abbreviated version!
For detailed information about dihydroorotate dehydrogenase (NAD+), go to the full flat file.

Word Map on EC 1.3.1.14

Reaction

(S)-dihydroorotate
+
NAD+
=
Orotate
+
NADH
+
H+

Synonyms

b-type dihydroorotate dehydrogenase, DHO dehydrogenase, DHODase, DHOdehase A, dihydro-orotic dehydrogenase, dihydroorotate dehydrogenase, dihydrorotate dehydrogenase B, L-5,6-dihydro-orotate:NAD oxidoreductase, More, orotate reductase, reductase, orotate

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.14 dihydroorotate dehydrogenase (NAD+)

Reference

Reference on EC 1.3.1.14 - dihydroorotate dehydrogenase (NAD+)

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Friedmann, H.C.; Vennesland, B.
Purification and properties of diihydroorotic dehydrogenase
J. Biol. Chem.
233
1398-1406
1958
Faecalicatena orotica
Manually annotated by BRENDA team
Lieberman, I.; Kornberg, A.
Enzymic synthesis and breakdown of a pyrimidine, orotic acid. I. Dihydro-orotic dehydrogenase
Biochim. Biophys. Acta
12
223-234
1953
Faecalicatena orotica
Manually annotated by BRENDA team
Blattmann, P.; Retey, J.
Stereospecificity of the dihydroorotate-dehydrogenase reaction
Eur. J. Biochem.
30
130-137
1972
Faecalicatena orotica
Manually annotated by BRENDA team
Friedmann, H.C.; Krakow, G.
Bestimmung mit Dihydroorotat-Dehydrogenase
Methods Enzym. Anal. , 3rd Ed. (Bergmeyer, H. U. , ed. )
2
2010-2014
1984
Faecalicatena orotica
-
Manually annotated by BRENDA team
Buntain, I.G.; Suckling, C.J.; Wood, H.C.S.
Latent Inhibitors. Part 4. Irreversible inhibition of dihydro-orotate dehydrogenase by hydantoins derived from amino acids
J. Chem. Soc. Perkin Trans. I
1988
3175-3182
1988
Faecalicatena orotica
-
Manually annotated by BRENDA team
Friedmann, H.C.; Vennesland, B.
Crystalline dihydroorotic dehydrogenase
J. Biol. Chem.
235
1526-1530
1960
Faecalicatena orotica
Manually annotated by BRENDA team
Nelson, C.A.; Handler, P.
Preparation of bovine xanthine oxidase and the subunit structures of some iron flavoproteins
J. Biol. Chem.
243
5368-5373
1968
Faecalicatena orotica
Manually annotated by BRENDA team
Argyrou, A.; Washabaugh, M.W.; Pickart, C.M.
Dihydroorotate dehydrogenase from Clostridium oroticum is a class 1B enzyme and utilizes a concerted mechanism of catalysis
Biochemistry
39
10373-10384
2000
Bacillus subtilis, Enterococcus faecalis, Faecalicatena orotica, Lactococcus lactis
Manually annotated by BRENDA team
Rowland, P.; Norager, S.; Jensen, K.F.; Larsen, S.
Structure of dihydroorotate dehydrogenase B: electron transfer between two flavin groups bridged by an iron-sulphur cluster
Structure
8
1227-1238
2000
Bacillus subtilis, Enterococcus faecalis, Faecalicatena orotica, Lactococcus lactis
Manually annotated by BRENDA team
Andersen, P.S.; Jansen, P.J.G.; Hammer, K.
Two different dihydroorotate dehydrogenases in Lactococcus lactis
J. Bacteriol.
176
3975-3982
1994
Lactococcus lactis (A2RJT9), Lactococcus lactis
Manually annotated by BRENDA team
Kahler, A.E.; Nielsen, F.S.; Switzer, R.L.
Biochemical characterization of the heteromeric Bacillus subtilis dihydroorotate dehydrogenase and its isolated subunits
Arch. Biochem. Biophys.
371
191-201
1999
Bacillus subtilis, Mus musculus
Manually annotated by BRENDA team
Marcinkeviciene, J.; Tinney, L.M.; Wang, K.H.; Rogers, M.J.; Copeland, R.A.
Dihydroorotate dehydrogenase B of Enterococcus faecalis. Characterization and insights into chemical mechanism
Biochemistry
38
13129-13137
1999
Enterococcus faecalis
Manually annotated by BRENDA team
Mohsen, A.W.; Rigby, S.E.; Jensen, K.F.; Munro, A.W.; Scrutton, N.S.
Thermodynamic basis of electron transfer in dihydroorotate dehydrogenase B from Lactococcus lactis: analysis by potentiometry, EPR spectroscopy, and ENDOR spectroscopy
Biochemistry
43
6498-6510
2004
Lactococcus lactis
Manually annotated by BRENDA team
Combe, J.P.; Basran, J.; Hothi, P.; Leys, D.; Rigby, S.E.; Munro, A.W.; Scrutton, N.S.
Lys-D48 is required for charge stabilization, rapid flavin reduction, and internal electron transfer in the catalytic cycle of dihydroorotate dehydrogenase B of Lactococcus lactis
J. Biol. Chem.
281
17977-17988
2006
Lactococcus lactis
Manually annotated by BRENDA team
Kawasaki, S.; Satoh, T.; Todoroki, M.; Niimura, Y.
b-Type dihydroorotate dehydrogenase is purified as a H2O2-forming NADH oxidase from Bifidobacterium bifidum
Appl. Environ. Microbiol.
75
629-636
2009
Bifidobacterium bifidum (B7X933), Bifidobacterium bifidum
Manually annotated by BRENDA team